ID   ESXB_STAAC              Reviewed;         104 AA.
AC   Q5HJ84;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Type VII secretion system extracellular protein B {ECO:0000250|UniProtKB:P0C047};
DE            Short=Ess extracellular protein B {ECO:0000250|UniProtKB:P0C047};
GN   Name=esxB {ECO:0000250|UniProtKB:P0C047}; OrderedLocusNames=SACOL0278;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Virulence factor that is important for the establishment of
CC       infection in the host. EsxB is required for EsxA synthesis as well as
CC       secretion (By similarity). Mediates together with EsxA the release of
CC       S.aureus from the host cell. Inhibits also host cytokine production and
CC       thus modulates dendritic cell-mediated immunity (By similarity).
CC       {ECO:0000250|UniProtKB:A0A0H2XIE9, ECO:0000250|UniProtKB:P0C047}.
CC   -!- SUBUNIT: Homodimer. When mixed with EsxA does not form heterodimers.
CC       {ECO:0000250|UniProtKB:Q2G182}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0C047}.
CC       Note=Secreted via the ESAT-6 secretion system (Ess) / type VII
CC       secretion system (T7SS). {ECO:0000250|UniProtKB:P0C047}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. {ECO:0000305}.
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DR   EMBL; CP000046; AAW38832.1; -; Genomic_DNA.
DR   RefSeq; WP_000509668.1; NC_002951.2.
DR   AlphaFoldDB; Q5HJ84; -.
DR   SMR; Q5HJ84; -.
DR   EnsemblBacteria; AAW38832; AAW38832; SACOL0278.
DR   GeneID; 66838592; -.
DR   KEGG; sac:SACOL0278; -.
DR   HOGENOM; CLU_2248426_0_0_9; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
PE   3: Inferred from homology;
KW   Secreted; Virulence.
FT   CHAIN           1..104
FT                   /note="Type VII secretion system extracellular protein B"
FT                   /id="PRO_0000167830"
SQ   SEQUENCE   104 AA;  11510 MW;  836DC8438CCFD80B CRC64;
     MGGYKGIKAD GGKVDQAKQL AAKTAKDIEA CQKQTQQLAE YIEGSDWEGQ FANKVKDVLL
     IMAKFQEELV QPMADHQKAI DNLSQNLAKY DTLSIKQGLD RVNP