ID   ESXB_STAAS              Reviewed;         104 AA.
AC   Q6GCI3;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Type VII secretion system extracellular protein B {ECO:0000250|UniProtKB:P0C047};
DE            Short=Ess extracellular protein B {ECO:0000250|UniProtKB:P0C047};
GN   Name=esxB {ECO:0000250|UniProtKB:P0C047}; OrderedLocusNames=SAS0265;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Virulence factor that is important for the establishment of
CC       infection in the host. EsxB is required for EsxA synthesis as well as
CC       secretion (By similarity). Mediates together with EsxA the release of
CC       S.aureus from the host cell. Inhibits also host cytokine production and
CC       thus modulates dendritic cell-mediated immunity (By similarity).
CC       {ECO:0000250|UniProtKB:A0A0H2XIE9, ECO:0000250|UniProtKB:P0C047}.
CC   -!- SUBUNIT: Homodimer. When mixed with EsxA does not form heterodimers.
CC       {ECO:0000250|UniProtKB:Q2G182}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0C047}.
CC       Note=Secreted via the ESAT-6 secretion system (Ess) / type VII
CC       secretion system (T7SS). {ECO:0000250|UniProtKB:P0C047}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. {ECO:0000305}.
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DR   EMBL; BX571857; CAG42036.1; -; Genomic_DNA.
DR   RefSeq; WP_000509667.1; NC_002953.3.
DR   AlphaFoldDB; Q6GCI3; -.
DR   SMR; Q6GCI3; -.
DR   KEGG; sas:SAS0265; -.
DR   HOGENOM; CLU_2248426_0_0_9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
PE   3: Inferred from homology;
KW   Secreted; Virulence.
FT   CHAIN           1..104
FT                   /note="Type VII secretion system extracellular protein B"
FT                   /id="PRO_0000167833"
SQ   SEQUENCE   104 AA;  11492 MW;  EF0708438CCFD80F CRC64;
     MGGYKGIKAD GGKVDQAKQL AAKTAKDIEA CQKQTQQLAE YIEGSDWEGQ FANKVKDVLL
     IMAKFQEELV QPIADHQKAI DNLSQNLAKY DTLSIKQGLD RVNP