ID   ESXC_STAA3              Reviewed;         130 AA.
AC   A0A0H2XIK2;
DT   05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT   16-SEP-2015, sequence version 1.
DT   25-MAY-2022, entry version 19.
DE   RecName: Full=Type VII secretion system extracellular protein C {ECO:0000305};
DE            Short=Ess extracellular protein C {ECO:0000305};
GN   Name=esxC {ECO:0000303|PubMed:24033479};
GN   Synonyms=esaC {ECO:0000303|PubMed:24033479};
GN   OrderedLocusNames=SAUSA300_0284 {ECO:0000312|EMBL:ABD22823.1};
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300;
RX   PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
RN   [2]
RP   SUBUNIT, AND SUBCELLULAR LOCATION.
RC   STRAIN=USA300;
RX   PubMed=24033479; DOI=10.1111/mmi.12395;
RA   Anderson M., Aly K.A., Chen Y.H., Missiakas D.;
RT   "Secretion of atypical protein substrates by the ESAT-6 secretion system of
RT   Staphylococcus aureus.";
RL   Mol. Microbiol. 90:734-743(2013).
RN   [3]
RP   SUBUNIT.
RX   PubMed=29499245; DOI=10.1016/j.toxicon.2018.02.047;
RA   Abd El-Fatah R.M., Mesbah N.M., Abo-Elmatty D.M., Aly K.A.;
RT   "The C-terminus of the ESAT6-like secretion system virulence factor EsxC
RT   mediates divalent cation-dependent homodimerization.";
RL   Toxicon 146:129-137(2018).
CC   -!- SUBUNIT: Forms both homodimers and heterodimers with EsxA
CC       (PubMed:24033479). Homodimerization is calcium-dependent
CC       (PubMed:29499245). {ECO:0000269|PubMed:24033479,
CC       ECO:0000269|PubMed:29499245}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24033479}.
CC       Note=Secreted via the ESAT-6 secretion system (Ess) / type VII
CC       secretion system (T7SS). {ECO:0000250|UniProtKB:P0C051}.
CC   -!- SIMILARITY: Belongs to the EsxC family. {ECO:0000305}.
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DR   EMBL; CP000255; ABD22823.1; -; Genomic_DNA.
DR   RefSeq; WP_001010289.1; NZ_CP027476.1.
DR   AlphaFoldDB; A0A0H2XIK2; -.
DR   SMR; A0A0H2XIK2; -.
DR   EnsemblBacteria; ABD22823; ABD22823; SAUSA300_0284.
DR   GeneID; 66838591; -.
DR   KEGG; saa:SAUSA300_0284; -.
DR   HOGENOM; CLU_1936813_0_0_9; -.
DR   Proteomes; UP000001939; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Secreted; Virulence.
FT   CHAIN           1..130
FT                   /note="Type VII secretion system extracellular protein C"
FT                   /id="PRO_0000437375"
SQ   SEQUENCE   130 AA;  14937 MW;  E4ADDB26B7706A8F CRC64;
     MNFNDIETMV KSKFKDIKKH AEEIAHEIEV RSGYLRKAEQ YKRLEFNLSF ALDDIESTAK
     DVQTAKSSAN KDSVTVKGKA PNTLYIEKRN LMKQKLEMLG EDIDKNKESL QKAKEIAGEK
     ASEYFNKAMN