ID   ESXC_STAAE              Reviewed;         130 AA.
AC   P0C051; A6QDR4;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Type VII secretion system extracellular protein C {ECO:0000305};
DE            Short=Ess extracellular protein C {ECO:0000305};
GN   Name=esxC {ECO:0000250|UniProtKB:A0A0H2XIK2};
GN   Synonyms=esaC {ECO:0000303|PubMed:15657139}; OrderedLocusNames=NWMN_0224;
OS   Staphylococcus aureus (strain Newman).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=426430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Newman;
RX   PubMed=17951380; DOI=10.1128/jb.01000-07;
RA   Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT   "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT   analysis of staphylococcal genomes: polymorphism and evolution of two major
RT   pathogenicity islands.";
RL   J. Bacteriol. 190:300-310(2008).
RN   [2]
RP   FUNCTION IN VIRULENCE.
RC   STRAIN=Newman;
RX   PubMed=15657139; DOI=10.1073/pnas.0405620102;
RA   Burts M.L., Williams W.A., DeBord K., Missiakas D.M.;
RT   "EsxA and EsxB are secreted by an ESAT-6-like system that is required for
RT   the pathogenesis of Staphylococcus aureus infections.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:1169-1174(2005).
RN   [3]
RP   FUNCTION, SUBCELLULAR LOCATION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=Newman;
RX   PubMed=18554323; DOI=10.1111/j.1365-2958.2008.06324.x;
RA   Burts M.L., DeDent A.C., Missiakas D.M.;
RT   "EsaC substrate for the ESAT-6 secretion pathway and its role in persistent
RT   infections of Staphylococcus aureus.";
RL   Mol. Microbiol. 69:736-746(2008).
CC   -!- FUNCTION: Required for persistent infection.
CC       {ECO:0000269|PubMed:15657139, ECO:0000269|PubMed:18554323}.
CC   -!- SUBUNIT: Forms both homodimers and heterodimers with EsxA.
CC       Homodimerization is calcium-dependent.
CC       {ECO:0000250|UniProtKB:A0A0H2XIK2}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18554323}.
CC       Note=Secreted during infection via the ESAT-6 secretion system (Ess) /
CC       type VII secretion system (T7SS). {ECO:0000269|PubMed:18554323}.
CC   -!- INDUCTION: Negatively regulated by EsaB. {ECO:0000269|PubMed:18554323}.
CC   -!- DISRUPTION PHENOTYPE: Deletion mutants display only a small defect in
CC       acute infection, but remarkably are unable to promote persistent
CC       abscesses during animal infection. {ECO:0000269|PubMed:18554323}.
CC   -!- SIMILARITY: Belongs to the EsxC family. {ECO:0000305}.
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DR   EMBL; AP009351; BAF66496.1; -; Genomic_DNA.
DR   RefSeq; WP_001010289.1; NZ_CP023390.1.
DR   AlphaFoldDB; P0C051; -.
DR   SMR; P0C051; -.
DR   EnsemblBacteria; BAF66496; BAF66496; NWMN_0224.
DR   GeneID; 66838591; -.
DR   KEGG; sae:NWMN_0224; -.
DR   HOGENOM; CLU_1936813_0_0_9; -.
DR   Proteomes; UP000006386; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Secreted; Virulence.
FT   CHAIN           1..130
FT                   /note="Type VII secretion system extracellular protein C"
FT                   /id="PRO_0000087054"
SQ   SEQUENCE   130 AA;  14937 MW;  E4ADDB26B7706A8F CRC64;
     MNFNDIETMV KSKFKDIKKH AEEIAHEIEV RSGYLRKAEQ YKRLEFNLSF ALDDIESTAK
     DVQTAKSSAN KDSVTVKGKA PNTLYIEKRN LMKQKLEMLG EDIDKNKESL QKAKEIAGEK
     ASEYFNKAMN