ID   ESXC_STAAM              Reviewed;         130 AA.
AC   Q99WT8;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Type VII secretion system extracellular protein C {ECO:0000250|UniProtKB:P0C051};
DE            Short=Ess extracellular protein C {ECO:0000250|UniProtKB:P0C051};
GN   Name=esxC {ECO:0000250|UniProtKB:A0A0H2XIK2};
GN   Synonyms=esaC {ECO:0000303|PubMed:18554323}; OrderedLocusNames=SAV0289;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
RN   [2]
RP   FUNCTION.
RX   PubMed=18554323; DOI=10.1111/j.1365-2958.2008.06324.x;
RA   Burts M.L., DeDent A.C., Missiakas D.M.;
RT   "EsaC substrate for the ESAT-6 secretion pathway and its role in persistent
RT   infections of Staphylococcus aureus.";
RL   Mol. Microbiol. 69:736-746(2008).
CC   -!- FUNCTION: Implements its pathogenic function during infection.
CC       {ECO:0000269|PubMed:18554323}.
CC   -!- SUBUNIT: Forms both homodimers and heterodimers with EsxA.
CC       Homodimerization is calcium-dependent.
CC       {ECO:0000250|UniProtKB:A0A0H2XIK2}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0C051}.
CC       Note=Secreted via the ESAT-6 secretion system (Ess) / type VII
CC       secretion system (T7SS). {ECO:0000250|UniProtKB:P0C051}.
CC   -!- SIMILARITY: Belongs to the EsxC family. {ECO:0000305}.
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DR   EMBL; BA000017; BAB56451.1; -; Genomic_DNA.
DR   RefSeq; WP_001010292.1; NC_002758.2.
DR   AlphaFoldDB; Q99WT8; -.
DR   SMR; Q99WT8; -.
DR   TCDB; 3.A.7.17.1; the type iv (conjugal dna-protein transfer or virb) secretory pathway (ivsp) family.
DR   PaxDb; Q99WT8; -.
DR   EnsemblBacteria; BAB56451; BAB56451; SAV0289.
DR   KEGG; sav:SAV0289; -.
DR   HOGENOM; CLU_1936813_0_0_9; -.
DR   BioCyc; SAUR158878:SAV_RS01620-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Secreted; Virulence.
FT   CHAIN           1..130
FT                   /note="Type VII secretion system extracellular protein C"
FT                   /id="PRO_0000087051"
SQ   SEQUENCE   130 AA;  14803 MW;  A24DD7E2DCD8A233 CRC64;
     MNFNDIETMV KSKFKDIKKH AEEIAHEIEV RSGYLRKAEQ YKRLEFNLSI ALDDVESTAK
     DVQTAKSSAN KDSVSVKGKA PNTLYIEKRN LMKQKLEMLG EDIDKNKESL QKAKGIAGEK
     ASEYFNKAMN