ID   ESXC_STAAS              Reviewed;         130 AA.
AC   Q6GCI4;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=ESAT-6 secretion system extracellular protein C {ECO:0000250|UniProtKB:P0C051};
DE            Short=Ess extracellular protein C {ECO:0000250|UniProtKB:P0C051};
GN   Name=esxC {ECO:0000250|UniProtKB:A0A0H2XIK2};
GN   Synonyms=esaC {ECO:0000250|UniProtKB:P0C051}; OrderedLocusNames=SAS0264;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0C051}.
CC       Note=Secreted via the ESAT-6 secretion system (Ess) / type VII
CC       secretion system (T7SS). {ECO:0000250|UniProtKB:P0C051}.
CC   -!- SIMILARITY: Belongs to the EsxC family. {ECO:0000305}.
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DR   EMBL; BX571857; CAG42035.1; -; Genomic_DNA.
DR   RefSeq; WP_001010291.1; NC_002953.3.
DR   AlphaFoldDB; Q6GCI4; -.
DR   SMR; Q6GCI4; -.
DR   KEGG; sas:SAS0264; -.
DR   HOGENOM; CLU_1936813_0_0_9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Secreted; Virulence.
FT   CHAIN           1..130
FT                   /note="ESAT-6 secretion system extracellular protein C"
FT                   /id="PRO_0000087053"
SQ   SEQUENCE   130 AA;  14951 MW;  E0BDDF32A7706A88 CRC64;
     MNFNDIETMV KSKFKDIKKH AEEIAHEIEV RSGYLRKAEQ YKRLEFNLSF ALDDIESTAK
     DVQTAKTSAN KDSVTVKGKA PNTLYIEKRN LMKQKLEMLG EDIDKNKESL QKAKEIAGEK
     ASEYFNKAMN