ID   ESXC_STAAW              Reviewed;         130 AA.
AC   Q8NYF2;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Type VII secretion system extracellular protein C {ECO:0000250|UniProtKB:P0C051};
DE            Short=Ess extracellular protein C {ECO:0000250|UniProtKB:P0C051};
GN   Name=esxC {ECO:0000250|UniProtKB:A0A0H2XIK2};
GN   Synonyms=esaC {ECO:0000303|PubMed:18554323}; OrderedLocusNames=MW0264;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
RN   [2]
RP   FUNCTION.
RX   PubMed=18554323; DOI=10.1111/j.1365-2958.2008.06324.x;
RA   Burts M.L., DeDent A.C., Missiakas D.M.;
RT   "EsaC substrate for the ESAT-6 secretion pathway and its role in persistent
RT   infections of Staphylococcus aureus.";
RL   Mol. Microbiol. 69:736-746(2008).
CC   -!- FUNCTION: Implements its pathogenic function during infection.
CC       {ECO:0000269|PubMed:18554323}.
CC   -!- SUBUNIT: Forms both homodimers and heterodimers with EsxA.
CC       Homodimerization is calcium-dependent.
CC       {ECO:0000250|UniProtKB:A0A0H2XIK2}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0C051}.
CC       Note=Secreted via the ESAT-6 secretion system (Ess) / type VII
CC       secretion system (T7SS). {ECO:0000250|UniProtKB:P0C051}.
CC   -!- SIMILARITY: Belongs to the EsxC family. {ECO:0000305}.
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DR   EMBL; BA000033; BAB94129.1; -; Genomic_DNA.
DR   RefSeq; WP_001010291.1; NC_003923.1.
DR   AlphaFoldDB; Q8NYF2; -.
DR   SMR; Q8NYF2; -.
DR   EnsemblBacteria; BAB94129; BAB94129; BAB94129.
DR   KEGG; sam:MW0264; -.
DR   HOGENOM; CLU_1936813_0_0_9; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Secreted; Virulence.
FT   CHAIN           1..130
FT                   /note="Type VII secretion system extracellular protein C"
FT                   /id="PRO_0000087055"
SQ   SEQUENCE   130 AA;  14951 MW;  E0BDDF32A7706A88 CRC64;
     MNFNDIETMV KSKFKDIKKH AEEIAHEIEV RSGYLRKAEQ YKRLEFNLSF ALDDIESTAK
     DVQTAKTSAN KDSVTVKGKA PNTLYIEKRN LMKQKLEMLG EDIDKNKESL QKAKEIAGEK
     ASEYFNKAMN