ID   ESXE_MYCTO              Reviewed;          90 AA.
AC   P9WNH8; L0TDW8; O05441;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=ESAT-6-like protein EsxE {ECO:0000250|UniProtKB:P9WNH9};
GN   Name=esxE {ECO:0000303|PubMed:17088352};
GN   OrderedLocusNames=MT4023 {ECO:0000312|EMBL:AAK48387.1};
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
RN   [2]
RP   INDUCTION.
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=17088352; DOI=10.1128/iai.01395-06;
RA   Agarwal N., Woolwine S.C., Tyagi S., Bishai W.R.;
RT   "Characterization of the Mycobacterium tuberculosis sigma factor SigM by
RT   assessment of virulence and identification of SigM-dependent genes.";
RL   Infect. Immun. 75:452-461(2007).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P9WNH9}.
CC       Note=Probably secreted via the ESX / type VII secretion system (T7SS).
CC       {ECO:0000250|UniProtKB:P9WNH9}.
CC   -!- INDUCTION: Transcriptionally regulated by the sigma factor SigM.
CC       {ECO:0000269|PubMed:17088352}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. ESAT-6 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK48387.1; -; Genomic_DNA.
DR   PIR; A70600; A70600.
DR   RefSeq; WP_003400094.1; NZ_KK341228.1.
DR   AlphaFoldDB; P9WNH8; -.
DR   SMR; P9WNH8; -.
DR   EnsemblBacteria; AAK48387; AAK48387; MT4023.
DR   KEGG; mtc:MT4023; -.
DR   PATRIC; fig|83331.31.peg.4328; -.
DR   HOGENOM; CLU_151185_4_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
PE   2: Evidence at transcript level;
KW   Secreted.
FT   CHAIN           1..90
FT                   /note="ESAT-6-like protein EsxE"
FT                   /id="PRO_0000427124"
SQ   SEQUENCE   90 AA;  9603 MW;  83AB18F16E023B9E CRC64;
     MDPTVLADAV ARMAEFGRHV EELVAEIESL VTRLHVTWTG EGAAAHAEAQ RHWAAGEAMM
     RQALAQLTAA GQSAHANYTG AMATNLGMWS