ID   ESXE_MYCTU              Reviewed;          90 AA.
AC   P9WNH9; L0TDW8; O05441;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=ESAT-6-like protein EsxE {ECO:0000305};
GN   Name=esxE {ECO:0000303|PubMed:19876390}; OrderedLocusNames=Rv3904c;
GN   ORFNames=MTCY15F10.07;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=19876390; DOI=10.1371/journal.ppat.1000507;
RA   Bitter W., Houben E.N., Bottai D., Brodin P., Brown E.J., Cox J.S.,
RA   Derbyshire K., Fortune S.M., Gao L.Y., Liu J., Gey van Pittius N.C.,
RA   Pym A.S., Rubin E.J., Sherman D.R., Cole S.T., Brosch R.;
RT   "Systematic genetic nomenclature for type VII secretion systems.";
RL   PLoS Pathog. 5:E1000507-E1000507(2009).
RN   [3]
RP   SUBUNIT.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=20085764; DOI=10.1016/j.febslet.2009.12.057;
RA   Poulsen C., Holton S., Geerlof A., Wilmanns M., Song Y.H.;
RT   "Stoichiometric protein complex formation and over-expression using the
RT   prokaryotic native operon structure.";
RL   FEBS Lett. 584:669-674(2010).
CC   -!- SUBUNIT: Forms a tight 1:1 complex with EsxF (PubMed:20085764).
CC       {ECO:0000269|PubMed:20085764}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:19876390}.
CC       Note=Probably secreted via the ESX / type VII secretion system (T7SS).
CC       {ECO:0000305|PubMed:19876390}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. ESAT-6 subfamily.
CC       {ECO:0000305|PubMed:19876390}.
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DR   EMBL; AL123456; CCP46733.1; -; Genomic_DNA.
DR   PIR; A70600; A70600.
DR   RefSeq; NP_218421.1; NC_000962.3.
DR   RefSeq; WP_003400094.1; NC_000962.3.
DR   AlphaFoldDB; P9WNH9; -.
DR   SMR; P9WNH9; -.
DR   STRING; 83332.Rv3904c; -.
DR   PaxDb; P9WNH9; -.
DR   DNASU; 886237; -.
DR   GeneID; 886237; -.
DR   KEGG; mtu:Rv3904c; -.
DR   PATRIC; fig|83332.111.peg.4348; -.
DR   TubercuList; Rv3904c; -.
DR   eggNOG; COG4842; Bacteria.
DR   OMA; LRATWHG; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Secreted.
FT   CHAIN           1..90
FT                   /note="ESAT-6-like protein EsxE"
FT                   /id="PRO_0000167819"
SQ   SEQUENCE   90 AA;  9603 MW;  83AB18F16E023B9E CRC64;
     MDPTVLADAV ARMAEFGRHV EELVAEIESL VTRLHVTWTG EGAAAHAEAQ RHWAAGEAMM
     RQALAQLTAA GQSAHANYTG AMATNLGMWS