ID   ESXF_MYCTO              Reviewed;         103 AA.
AC   P9WNH6; L0TE47; O05440;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=ESAT-6-like protein EsxF {ECO:0000250|UniProtKB:P9WNH7};
GN   Name=esxF {ECO:0000303|PubMed:17088352}; OrderedLocusNames=MT4024;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
RN   [2]
RP   INDUCTION.
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=17088352; DOI=10.1128/iai.01395-06;
RA   Agarwal N., Woolwine S.C., Tyagi S., Bishai W.R.;
RT   "Characterization of the Mycobacterium tuberculosis sigma factor SigM by
RT   assessment of virulence and identification of SigM-dependent genes.";
RL   Infect. Immun. 75:452-461(2007).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P9WNH7}.
CC       Note=Probably secreted via the ESX / type VII secretion system (T7SS).
CC       {ECO:0000250|UniProtKB:P9WNH7}.
CC   -!- INDUCTION: Transcriptionally regulated by the sigma factor SigM.
CC       {ECO:0000269|PubMed:17088352}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. CFP-10 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK48388.1; -; Genomic_DNA.
DR   PIR; B70600; B70600.
DR   RefSeq; WP_003400100.1; NZ_KK341228.1.
DR   AlphaFoldDB; P9WNH6; -.
DR   SMR; P9WNH6; -.
DR   EnsemblBacteria; AAK48388; AAK48388; MT4024.
DR   GeneID; 45427905; -.
DR   KEGG; mtc:MT4024; -.
DR   PATRIC; fig|83331.31.peg.4329; -.
DR   HOGENOM; CLU_157917_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
DR   TIGRFAMs; TIGR03930; WXG100_ESAT6; 1.
PE   2: Evidence at transcript level;
KW   Secreted.
FT   CHAIN           1..103
FT                   /note="ESAT-6-like protein EsxF"
FT                   /id="PRO_0000427125"
SQ   SEQUENCE   103 AA;  10460 MW;  3994E272A7BDFF02 CRC64;
     MGADDTLRVE PAVMQGFAAS LDGAAEHLAV QLAELDAQVG QMLGGWRGAS GSAYGSAWEL
     WHRGAGEVQL GLSMLAAAIA HAGAGYQHNE TASAQVLREV GGG