ID   ESXG_MYCS2              Reviewed;          97 AA.
AC   A0QQ43;
DT   09-DEC-2015, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=ESAT-6-like protein EsxG {ECO:0000305};
GN   Name=esxG {ECO:0000303|PubMed:24803520};
GN   OrderedLocusNames=MSMEG_0620 {ECO:0000312|EMBL:ABK71673.1},
GN   MSMEI_0604 {ECO:0000312|EMBL:AFP37085.1};
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA   Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA   Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT   "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT   mutations or sequencing errors?";
RL   Genome Biol. 8:R20.1-R20.9(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=18955433; DOI=10.1101/gr.081901.108;
RA   Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA   Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT   "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT   and a new MS-based protocol.";
RL   Genome Res. 19:128-135(2009).
RN   [4]
RP   SUBCELLULAR LOCATION.
RX   PubMed=24803520; DOI=10.1128/mbio.01073-14;
RA   Siegrist M.S., Steigedal M., Ahmad R., Mehra A., Dragset M.S.,
RA   Schuster B.M., Philips J.A., Carr S.A., Rubin E.J.;
RT   "Mycobacterial Esx-3 requires multiple components for iron acquisition.";
RL   MBio 5:E01073-E01073(2014).
RN   [5] {ECO:0007744|PDB:3Q4H}
RP   X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) IN COMPLEX WITH ESXH.
RX   PubMed=24312350; DOI=10.1371/journal.pone.0081753;
RA   Arbing M.A., Chan S., Harris L., Kuo E., Zhou T.T., Ahn C.J., Nguyen L.,
RA   He Q., Lu J., Menchavez P.T., Shin A., Holton T., Sawaya M.R., Cascio D.,
RA   Eisenberg D.;
RT   "Heterologous expression of mycobacterial Esx complexes in Escherichia coli
RT   for structural studies is facilitated by the use of maltose binding protein
RT   fusions.";
RL   PLoS ONE 8:E81753-E81753(2013).
CC   -!- SUBUNIT: Forms a tight 1:1 complex with EsxH.
CC       {ECO:0000269|PubMed:24312350}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24803520}.
CC       Note=Secreted via the ESX-3 / type VII secretion system (T7SS).
CC       {ECO:0000269|PubMed:24803520}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. CFP-10 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; CP000480; ABK71673.1; -; Genomic_DNA.
DR   EMBL; CP001663; AFP37085.1; -; Genomic_DNA.
DR   RefSeq; WP_011727071.1; NZ_SIJM01000009.1.
DR   RefSeq; YP_885031.1; NC_008596.1.
DR   PDB; 3Q4H; X-ray; 2.70 A; A/C=1-97.
DR   PDBsum; 3Q4H; -.
DR   AlphaFoldDB; A0QQ43; -.
DR   SMR; A0QQ43; -.
DR   STRING; 246196.MSMEI_0604; -.
DR   EnsemblBacteria; ABK71673; ABK71673; MSMEG_0620.
DR   EnsemblBacteria; AFP37085; AFP37085; MSMEI_0604.
DR   GeneID; 66738798; -.
DR   KEGG; msg:MSMEI_0604; -.
DR   KEGG; msm:MSMEG_0620; -.
DR   PATRIC; fig|246196.19.peg.616; -.
DR   eggNOG; ENOG5030NJS; Bacteria.
DR   OMA; ASHARFI; -.
DR   EvolutionaryTrace; A0QQ43; -.
DR   Proteomes; UP000000757; Chromosome.
DR   Proteomes; UP000006158; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   SUPFAM; SSF140453; SSF140453; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Secreted.
FT   CHAIN           1..97
FT                   /note="ESAT-6-like protein EsxG"
FT                   /id="PRO_0000434998"
FT   HELIX           7..37
FT                   /evidence="ECO:0007829|PDB:3Q4H"
FT   TURN            38..42
FT                   /evidence="ECO:0007829|PDB:3Q4H"
FT   HELIX           46..76
FT                   /evidence="ECO:0007829|PDB:3Q4H"
FT   HELIX           78..93
FT                   /evidence="ECO:0007829|PDB:3Q4H"
SQ   SEQUENCE   97 AA;  9940 MW;  EEC69610D3632002 CRC64;
     MSLLDAHIPQ LIASEANFGA KAALMRSTIA QAEQAAMSSQ AFHMGEASAA FQAAHARFVE
     VSAKVNALLD IAQLNIGDAA SSYVAQDAAA ASTYTGI