ESXH_MYCBO
ID ESXH_MYCBO Reviewed; 96 AA.
AC P0A569; A0A1R3XUX6; O53693; X2BEL4;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=ESAT-6-like protein EsxH {ECO:0000250|UniProtKB:P9WNK3};
DE AltName: Full=10 kDa antigen CFP7 {ECO:0000250|UniProtKB:P9WNK3};
DE Short=CFP-7 {ECO:0000250|UniProtKB:P9WNK3};
DE AltName: Full=Low molecular weight protein antigen 7 {ECO:0000250|UniProtKB:P9WNK3};
DE AltName: Full=Protein TB10.4 {ECO:0000250|UniProtKB:P9WNK3};
GN Name=esxH {ECO:0000250|UniProtKB:P9WNK3}; Synonyms=cfp7;
GN OrderedLocusNames=BQ2027_MB0296;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
CC -!- SUBUNIT: Forms a tight 1:1 complex with EsxG.
CC {ECO:0000250|UniProtKB:P9WNK3}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P9WNK3}.
CC Note=Secreted via the ESX-3 / type VII secretion system (T7SS).
CC {ECO:0000250|UniProtKB:P9WNK3}.
CC -!- SIMILARITY: Belongs to the WXG100 family. ESAT-6 subfamily.
CC {ECO:0000305}.
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DR EMBL; LT708304; SIT98824.1; -; Genomic_DNA.
DR RefSeq; NP_853960.1; NC_002945.3.
DR RefSeq; WP_003401514.1; NC_002945.4.
DR AlphaFoldDB; P0A569; -.
DR BMRB; P0A569; -.
DR SMR; P0A569; -.
DR GeneID; 45424262; -.
DR PATRIC; fig|233413.5.peg.324; -.
DR OMA; HEANTMS; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR036689; ESAT-6-like_sf.
DR InterPro; IPR010310; T7SS_ESAT-6-like.
DR Pfam; PF06013; WXG100; 1.
DR SUPFAM; SSF140453; SSF140453; 1.
DR TIGRFAMs; TIGR03930; WXG100_ESAT6; 1.
PE 3: Inferred from homology;
KW Metal-binding; Secreted; Zinc.
FT CHAIN 1..96
FT /note="ESAT-6-like protein EsxH"
FT /id="PRO_0000167797"
FT BINDING 14
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P9WNK3"
FT BINDING 70
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P9WNK3"
FT BINDING 76
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P9WNK3"
FT BINDING 77
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P9WNK3"
SQ SEQUENCE 96 AA; 10391 MW; EC47BE7E10690437 CRC64;
MSQIMYNYPA MLGHAGDMAG YAGTLQSLGA EIAVEQAALQ SAWQGDTGIT YQAWQAQWNQ
AMEDLVRAYH AMSSTHEANT MAMMARDTAE AAKWGG
