ESXH_MYCTO
ID ESXH_MYCTO Reviewed; 96 AA.
AC P9WNK2; L0T606; O53693; P0A568;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 34.
DE RecName: Full=ESAT-6-like protein EsxH {ECO:0000250|UniProtKB:P9WNK3};
DE AltName: Full=10 kDa antigen CFP7 {ECO:0000250|UniProtKB:P9WNK3};
DE Short=CFP-7 {ECO:0000250|UniProtKB:P9WNK3};
DE AltName: Full=Low molecular weight protein antigen 7 {ECO:0000250|UniProtKB:P9WNK3};
DE AltName: Full=Protein TB10.4 {ECO:0000250|UniProtKB:P9WNK3};
GN Name=esxH {ECO:0000250|UniProtKB:P9WNK3}; Synonyms=cfp7;
GN OrderedLocusNames=MT0301;
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- FUNCTION: EsxH, in complex with EsxG, disrupts ESCRT function and
CC impairs host phagosome maturation, thereby promoting intracellular
CC bacterial growth. The complex acts by interacting, via EsxH, with the
CC host hepatocyte growth factor-regulated tyrosine kinase substrate
CC (HGS/HRS), a component of the ESCRT machinery.
CC {ECO:0000250|UniProtKB:P9WNK3}.
CC -!- SUBUNIT: Forms a tight 1:1 complex with EsxG (By similarity). When it
CC is complexed to EsxG, interacts directly with host HGS/HRS (By
CC similarity). {ECO:0000250|UniProtKB:P9WNK3}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P9WNK3}.
CC Note=Secreted via the ESX-3 / type VII secretion system (T7SS).
CC {ECO:0000250|UniProtKB:P9WNK3}.
CC -!- SIMILARITY: Belongs to the WXG100 family. ESAT-6 subfamily.
CC {ECO:0000305}.
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DR EMBL; AE000516; AAK44525.1; -; Genomic_DNA.
DR PIR; F70836; F70836.
DR RefSeq; WP_003401514.1; NZ_KK341227.1.
DR AlphaFoldDB; P9WNK2; -.
DR BMRB; P9WNK2; -.
DR SMR; P9WNK2; -.
DR EnsemblBacteria; AAK44525; AAK44525; MT0301.
DR GeneID; 45424262; -.
DR KEGG; mtc:MT0301; -.
DR PATRIC; fig|83331.31.peg.324; -.
DR HOGENOM; CLU_2451485_0_0_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR036689; ESAT-6-like_sf.
DR InterPro; IPR010310; T7SS_ESAT-6-like.
DR Pfam; PF06013; WXG100; 1.
DR SUPFAM; SSF140453; SSF140453; 1.
DR TIGRFAMs; TIGR03930; WXG100_ESAT6; 1.
PE 3: Inferred from homology;
KW Metal-binding; Secreted; Virulence; Zinc.
FT CHAIN 1..96
FT /note="ESAT-6-like protein EsxH"
FT /id="PRO_0000427112"
FT BINDING 14
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P9WNK3"
FT BINDING 70
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P9WNK3"
FT BINDING 76
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P9WNK3"
FT BINDING 77
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000250|UniProtKB:P9WNK3"
SQ SEQUENCE 96 AA; 10391 MW; EC47BE7E10690437 CRC64;
MSQIMYNYPA MLGHAGDMAG YAGTLQSLGA EIAVEQAALQ SAWQGDTGIT YQAWQAQWNQ
AMEDLVRAYH AMSSTHEANT MAMMARDTAE AAKWGG
