ID   ESXI_MYCBO              Reviewed;          94 AA.
AC   P59802; A0A1R3XXI8; X2BGV7;
DT   04-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   04-AUG-2003, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=ESAT-6-like protein EsxI {ECO:0000250|UniProtKB:P0DOA6};
GN   Name=esxI {ECO:0000250|UniProtKB:P0DOA6}; OrderedLocusNames=BQ2027_MB1066C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P0DOA6}.
CC       Note=Probably secreted via the ESX-5 / type VII secretion system
CC       (T7SS). {ECO:0000250|UniProtKB:P0DOA6}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. ESAT-6 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; LT708304; SIT99665.1; -; Genomic_DNA.
DR   RefSeq; NP_854722.1; NC_002945.3.
DR   RefSeq; WP_003405333.1; NC_002945.4.
DR   AlphaFoldDB; P59802; -.
DR   SMR; P59802; -.
DR   EnsemblBacteria; SIT99665; SIT99665; BQ2027_MB1066C.
DR   GeneID; 45427605; -.
DR   PATRIC; fig|233413.5.peg.1159; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR009416; ESAT-6-like_Myco.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   PIRSF; PIRSF037656; DUF1066; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
PE   3: Inferred from homology;
KW   Secreted.
FT   CHAIN           1..94
FT                   /note="ESAT-6-like protein EsxI"
FT                   /id="PRO_0000167799"
SQ   SEQUENCE   94 AA;  9818 MW;  8F9701831E93F657 CRC64;
     MTINYQFGDV DAHGAMIRAL AGSLEAEHQA IISDVLTASD FWGGAGSAAC QGFITQLGRN
     FQVIYEQANA HGQKVQAAGN NMAQTDSAVG SSWA