ID   ESXI_MYCTU              Reviewed;          94 AA.
AC   P0DOA6; L0TEQ6; O08120; O08122; P96364; P9WNK1; Q9L781;
DT   07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
DT   07-SEP-2016, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=ESAT-6-like protein EsxI {ECO:0000305};
DE   AltName: Full=Antigen Mtb9.9B;
GN   Name=esxI {ECO:0000303|PubMed:19876390}; OrderedLocusNames=Rv1037c;
GN   ORFNames=MTCY10G2.12;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=10662800; DOI=10.1084/jem.191.3.551;
RA   Alderson M.R., Bement T., Day C.H., Zhu L., Molesh D., Skeiky Y.A.W.,
RA   Coler R., Lewinsohn D.M., Reed S.G., Dillon D.C.;
RT   "Expression cloning of an immunodominant family of Mycobacterium
RT   tuberculosis antigens using human CD4(+) T cells.";
RL   J. Exp. Med. 191:551-560(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [3]
RP   NOMENCLATURE.
RX   PubMed=19876390; DOI=10.1371/journal.ppat.1000507;
RA   Bitter W., Houben E.N., Bottai D., Brodin P., Brown E.J., Cox J.S.,
RA   Derbyshire K., Fortune S.M., Gao L.Y., Liu J., Gey van Pittius N.C.,
RA   Pym A.S., Rubin E.J., Sherman D.R., Cole S.T., Brosch R.;
RT   "Systematic genetic nomenclature for type VII secretion systems.";
RL   PLoS Pathog. 5:E1000507-E1000507(2009).
RN   [4]
RP   INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=22291682; DOI=10.3389/fmicb.2011.00266;
RA   Bukka A., Price C.T., Kernodle D.S., Graham J.E.;
RT   "Mycobacterium tuberculosis RNA expression patterns in sputum bacteria
RT   indicate secreted Esx factors contributing to growth are highly expressed
RT   in active disease.";
RL   Front. Microbiol. 2:266-266(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:19876390}.
CC       Note=Probably secreted via the ESX-5 / type VII secretion system
CC       (T7SS). {ECO:0000305|PubMed:19876390}.
CC   -!- INDUCTION: Differentially expressed under different growth conditions.
CC       {ECO:0000269|PubMed:22291682}.
CC   -!- DISRUPTION PHENOTYPE: EsxJI deletion mutant shows extremely slow growth
CC       in broth cultures. {ECO:0000269|PubMed:22291682}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. ESAT-6 subfamily.
CC       {ECO:0000305|PubMed:19876390}.
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DR   EMBL; AF226277; AAF32406.1; -; Genomic_DNA.
DR   EMBL; AL123456; CCP43788.1; -; Genomic_DNA.
DR   PIR; D70560; D70560.
DR   RefSeq; NP_215553.1; NC_000962.3.
DR   RefSeq; NP_218136.1; NC_000962.3.
DR   RefSeq; WP_003898699.1; NZ_NVQJ01000149.1.
DR   AlphaFoldDB; P0DOA6; -.
DR   SMR; P0DOA6; -.
DR   STRING; 83332.Rv1037c; -.
DR   DNASU; 888299; -.
DR   GeneID; 885328; -.
DR   GeneID; 888299; -.
DR   KEGG; mtu:Rv1037c; -.
DR   KEGG; mtu:Rv3619c; -.
DR   TubercuList; Rv1037c; -.
DR   eggNOG; ENOG5032I3T; Bacteria.
DR   PhylomeDB; P0DOA6; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; IDA:UniProtKB.
DR   InterPro; IPR009416; ESAT-6-like_Myco.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   PIRSF; PIRSF037656; DUF1066; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted.
FT   CHAIN           1..94
FT                   /note="ESAT-6-like protein EsxI"
FT                   /id="PRO_0000167800"
FT   CONFLICT        20
FT                   /note="Q -> L (in Ref. 1; AAF32406)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        23
FT                   /note="S -> L (in Ref. 1; AAF32406)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   94 AA;  9833 MW;  8F971BB03789C57E CRC64;
     MTINYQFGDV DAHGAMIRAQ AGSLEAEHQA IISDVLTASD FWGGAGSAAC QGFITQLGRN
     FQVIYEQANA HGQKVQAAGN NMAQTDSAVG SSWA