ID   ESXJ_MYCTU              Reviewed;          98 AA.
AC   P9WNJ9; L0T747; P96363;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=ESAT-6-like protein EsxJ {ECO:0000305};
GN   Name=esxJ {ECO:0000303|PubMed:19876390}; OrderedLocusNames=Rv1038c;
GN   ORFNames=MTCY10G2.11;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   STRAIN=ATCC 27294 / TMC 102 / H37Rv;
RX   PubMed=12919853; DOI=10.1016/s1286-4579(03)00179-5;
RA   He X.Y., Zhuang Y.H., Zhang X.G., Li G.L.;
RT   "Comparative proteome analysis of culture supernatant proteins of
RT   Mycobacterium tuberculosis H37Rv and H37Ra.";
RL   Microbes Infect. 5:851-856(2003).
RN   [3]
RP   NOMENCLATURE.
RX   PubMed=19876390; DOI=10.1371/journal.ppat.1000507;
RA   Bitter W., Houben E.N., Bottai D., Brodin P., Brown E.J., Cox J.S.,
RA   Derbyshire K., Fortune S.M., Gao L.Y., Liu J., Gey van Pittius N.C.,
RA   Pym A.S., Rubin E.J., Sherman D.R., Cole S.T., Brosch R.;
RT   "Systematic genetic nomenclature for type VII secretion systems.";
RL   PLoS Pathog. 5:E1000507-E1000507(2009).
RN   [4]
RP   INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=22291682; DOI=10.3389/fmicb.2011.00266;
RA   Bukka A., Price C.T., Kernodle D.S., Graham J.E.;
RT   "Mycobacterium tuberculosis RNA expression patterns in sputum bacteria
RT   indicate secreted Esx factors contributing to growth are highly expressed
RT   in active disease.";
RL   Front. Microbiol. 2:266-266(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12919853}.
CC       Note=Probably secreted via the ESX-5 / type VII secretion system
CC       (T7SS). {ECO:0000305|PubMed:19876390}.
CC   -!- INDUCTION: Differentially expressed under different growth conditions.
CC       {ECO:0000269|PubMed:22291682}.
CC   -!- DISRUPTION PHENOTYPE: EsxJI deletion mutant shows extremely slow growth
CC       in broth cultures. {ECO:0000269|PubMed:22291682}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. CFP-10 subfamily.
CC       {ECO:0000305|PubMed:19876390}.
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DR   EMBL; AL123456; CCP43789.1; -; Genomic_DNA.
DR   PIR; A70625; A70625.
DR   RefSeq; NP_215554.1; NC_000962.3.
DR   RefSeq; WP_003405345.1; NZ_KK339370.1.
DR   AlphaFoldDB; P9WNJ9; -.
DR   SMR; P9WNJ9; -.
DR   STRING; 83332.Rv1038c; -.
DR   PaxDb; P9WNJ9; -.
DR   GeneID; 45425009; -.
DR   GeneID; 888372; -.
DR   KEGG; mtu:Rv1038c; -.
DR   TubercuList; Rv1038c; -.
DR   eggNOG; COG4842; Bacteria.
DR   OMA; HAMRAMA; -.
DR   PhylomeDB; P9WNJ9; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
DR   TIGRFAMs; TIGR03930; WXG100_ESAT6; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Secreted.
FT   CHAIN           1..98
FT                   /note="ESAT-6-like protein EsxJ"
FT                   /id="PRO_0000167802"
SQ   SEQUENCE   98 AA;  10993 MW;  0ED04CBA64A779D1 CRC64;
     MASRFMTDPH AMRDMAGRFE VHAQTVEDEA RRMWASAQNI SGAGWSGMAE ATSLDTMTQM
     NQAFRNIVNM LHGVRDGLVR DANNYEQQEQ ASQQILSS