ID   ESXN_MYCTU              Reviewed;          94 AA.
AC   P9WNJ3; L0TAM3; O53942; P0A570;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=ESAT-6-like protein EsxN {ECO:0000305};
GN   Name=esxN {ECO:0000303|PubMed:19876390, ECO:0000303|PubMed:22925462};
GN   OrderedLocusNames=Rv1793; ORFNames=MTV049.15;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=19876390; DOI=10.1371/journal.ppat.1000507;
RA   Bitter W., Houben E.N., Bottai D., Brodin P., Brown E.J., Cox J.S.,
RA   Derbyshire K., Fortune S.M., Gao L.Y., Liu J., Gey van Pittius N.C.,
RA   Pym A.S., Rubin E.J., Sherman D.R., Cole S.T., Brosch R.;
RT   "Systematic genetic nomenclature for type VII secretion systems.";
RL   PLoS Pathog. 5:E1000507-E1000507(2009).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN   [4]
RP   SUBCELLULAR LOCATION.
RX   PubMed=22925462; DOI=10.1111/j.1365-2958.2012.08206.x;
RA   Houben E.N., Bestebroer J., Ummels R., Wilson L., Piersma S.R.,
RA   Jimenez C.R., Ottenhoff T.H., Luirink J., Bitter W.;
RT   "Composition of the type VII secretion system membrane complex.";
RL   Mol. Microbiol. 86:472-484(2012).
RN   [5]
RP   SUBCELLULAR LOCATION.
RX   PubMed=22340629; DOI=10.1111/j.1365-2958.2012.08001.x;
RA   Bottai D., Di Luca M., Majlessi L., Frigui W., Simeone R., Sayes F.,
RA   Bitter W., Brennan M.J., Leclerc C., Batoni G., Campa M., Brosch R.,
RA   Esin S.;
RT   "Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss
RT   of PPE protein secretion, reduction of cell wall integrity and strong
RT   attenuation.";
RL   Mol. Microbiol. 83:1195-1209(2012).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22340629,
CC       ECO:0000269|PubMed:22925462}. Note=Secreted via the ESX-5 / type VII
CC       secretion system (T7SS). {ECO:0000269|PubMed:22340629,
CC       ECO:0000269|PubMed:22925462}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. ESAT-6 subfamily.
CC       {ECO:0000305|PubMed:19876390}.
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DR   EMBL; AL123456; CCP44559.1; -; Genomic_DNA.
DR   PIR; B70930; B70930.
DR   RefSeq; WP_003408840.1; NZ_NVQJ01000037.1.
DR   RefSeq; YP_177838.1; NC_000962.3.
DR   AlphaFoldDB; P9WNJ3; -.
DR   SMR; P9WNJ3; -.
DR   STRING; 83332.Rv1793; -.
DR   PaxDb; P9WNJ3; -.
DR   DNASU; 885448; -.
DR   GeneID; 45426331; -.
DR   GeneID; 885448; -.
DR   KEGG; mtu:Rv1793; -.
DR   TubercuList; Rv1793; -.
DR   eggNOG; ENOG5032I3T; Bacteria.
DR   OMA; HGQKVQT; -.
DR   PhylomeDB; P9WNJ3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   InterPro; IPR009416; ESAT-6-like_Myco.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   PIRSF; PIRSF037656; DUF1066; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Secreted.
FT   CHAIN           1..94
FT                   /note="ESAT-6-like protein EsxN"
FT                   /id="PRO_0000167808"
SQ   SEQUENCE   94 AA;  9942 MW;  1B7AE4913129C8D8 CRC64;
     MTINYQFGDV DAHGAMIRAQ AASLEAEHQA IVRDVLAAGD FWGGAGSVAC QEFITQLGRN
     FQVIYEQANA HGQKVQAAGN NMAQTDSAVG SSWA