ID   ESXO_MYCTO              Reviewed;          94 AA.
AC   P9WNI6; L0T9C9; P95242;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=ESAT-6-like protein EsxO {ECO:0000250|UniProtKB:P9WNI7};
GN   Name=esxO {ECO:0000250|UniProtKB:P9WNI7}; OrderedLocusNames=MT2411;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBUNIT: Forms a complex with EsxP. {ECO:0000250|UniProtKB:P9WNI7}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P9WNI7}.
CC       Note=Probably secreted via the ESX-5 / type VII secretion system
CC       (T7SS). {ECO:0000250|UniProtKB:P9WNI7}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. ESAT-6 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK46704.1; -; Genomic_DNA.
DR   PIR; C70662; C70662.
DR   RefSeq; WP_003899283.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WNI6; -.
DR   SMR; P9WNI6; -.
DR   EnsemblBacteria; AAK46704; AAK46704; MT2411.
DR   KEGG; mtc:MT2411; -.
DR   PATRIC; fig|83331.31.peg.2599; -.
DR   HOGENOM; CLU_192559_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR009416; ESAT-6-like_Myco.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   PIRSF; PIRSF037656; DUF1066; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
PE   3: Inferred from homology;
KW   Secreted.
FT   CHAIN           1..94
FT                   /note="ESAT-6-like protein EsxO"
FT                   /id="PRO_0000427120"
SQ   SEQUENCE   94 AA;  9954 MW;  C740622D0BB7C8CA CRC64;
     MTINYQFGDV DAHGAMIRAQ AGLLEAEHQA IVRDVLAAGD FWGGAGSVAC QEFITQLGRN
     FQVIYEQANA HGQKVQAAGN NMAQTDSAVG SSWA