ID   ESXP_MYCTU              Reviewed;          98 AA.
AC   P9WNI5; L0T9J5; P95243;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=ESAT-6-like protein EsxP {ECO:0000305};
GN   Name=esxP {ECO:0000303|PubMed:19876390, ECO:0000303|PubMed:24312350};
GN   OrderedLocusNames=Rv2347c; ORFNames=MTCY98.16c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   STRAIN=ATCC 27294 / TMC 102 / H37Rv;
RX   PubMed=12919853; DOI=10.1016/s1286-4579(03)00179-5;
RA   He X.Y., Zhuang Y.H., Zhang X.G., Li G.L.;
RT   "Comparative proteome analysis of culture supernatant proteins of
RT   Mycobacterium tuberculosis H37Rv and H37Ra.";
RL   Microbes Infect. 5:851-856(2003).
RN   [3]
RP   NOMENCLATURE.
RX   PubMed=19876390; DOI=10.1371/journal.ppat.1000507;
RA   Bitter W., Houben E.N., Bottai D., Brodin P., Brown E.J., Cox J.S.,
RA   Derbyshire K., Fortune S.M., Gao L.Y., Liu J., Gey van Pittius N.C.,
RA   Pym A.S., Rubin E.J., Sherman D.R., Cole S.T., Brosch R.;
RT   "Systematic genetic nomenclature for type VII secretion systems.";
RL   PLoS Pathog. 5:E1000507-E1000507(2009).
RN   [4] {ECO:0007744|PDB:3OGI, ECO:0007744|PDB:4GZR}
RP   X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS), AND INTERACTION WITH ESXO.
RX   PubMed=24312350; DOI=10.1371/journal.pone.0081753;
RA   Arbing M.A., Chan S., Harris L., Kuo E., Zhou T.T., Ahn C.J., Nguyen L.,
RA   He Q., Lu J., Menchavez P.T., Shin A., Holton T., Sawaya M.R., Cascio D.,
RA   Eisenberg D.;
RT   "Heterologous expression of mycobacterial Esx complexes in Escherichia coli
RT   for structural studies is facilitated by the use of maltose binding protein
RT   fusions.";
RL   PLoS ONE 8:E81753-E81753(2013).
CC   -!- SUBUNIT: Forms a complex with EsxO. {ECO:0000269|PubMed:24312350}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12919853}.
CC       Note=Probably secreted via the ESX-5 / type VII secretion system
CC       (T7SS). {ECO:0000305|PubMed:19876390}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. CFP-10 subfamily.
CC       {ECO:0000305|PubMed:19876390}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL123456; CCP45135.1; -; Genomic_DNA.
DR   PIR; D70662; D70662.
DR   RefSeq; NP_216863.1; NC_000962.3.
DR   RefSeq; WP_003900502.1; NZ_NVQJ01000012.1.
DR   PDB; 3OGI; X-ray; 2.55 A; B/D=1-98.
DR   PDB; 4GZR; X-ray; 2.55 A; B/D=1-98.
DR   PDBsum; 3OGI; -.
DR   PDBsum; 4GZR; -.
DR   AlphaFoldDB; P9WNI5; -.
DR   SMR; P9WNI5; -.
DR   STRING; 83332.Rv2347c; -.
DR   PaxDb; P9WNI5; -.
DR   DNASU; 886002; -.
DR   GeneID; 886002; -.
DR   KEGG; mtu:Rv2347c; -.
DR   TubercuList; Rv2347c; -.
DR   eggNOG; COG4842; Bacteria.
DR   OMA; NIVTMLH; -.
DR   PhylomeDB; P9WNI5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
DR   TIGRFAMs; TIGR03930; WXG100_ESAT6; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Secreted.
FT   CHAIN           1..98
FT                   /note="ESAT-6-like protein EsxP"
FT                   /id="PRO_0000167815"
FT   HELIX           5..7
FT                   /evidence="ECO:0007829|PDB:4GZR"
FT   HELIX           9..38
FT                   /evidence="ECO:0007829|PDB:3OGI"
FT   HELIX           54..95
FT                   /evidence="ECO:0007829|PDB:3OGI"
SQ   SEQUENCE   98 AA;  10977 MW;  5AC41DEE70F269D6 CRC64;
     MATRFMTDPH AMRDMAGRFE VHAQTVEDEA RRMWASAQNI SGAGWSGMAE ATSLDTMAQM
     NQAFRNIVNM LHGVRDGLVR DANNYEQQEQ ASQQILSS