ID   ESXT_MYCTO              Reviewed;         100 AA.
AC   O06261; F2GIJ8; Q7D5J2;
DT   07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=ESAT-6-like protein EsxT {ECO:0000250|UniProtKB:I6YC53};
GN   Name=esxT {ECO:0000303|PubMed:17088352};
GN   OrderedLocusNames=MT3549 {ECO:0000312|EMBL:AAK47890.1};
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
RN   [2]
RP   INDUCTION.
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=17088352; DOI=10.1128/iai.01395-06;
RA   Agarwal N., Woolwine S.C., Tyagi S., Bishai W.R.;
RT   "Characterization of the Mycobacterium tuberculosis sigma factor SigM by
RT   assessment of virulence and identification of SigM-dependent genes.";
RL   Infect. Immun. 75:452-461(2007).
CC   -!- SUBUNIT: Forms a tight 1:1 complex with EsxU.
CC       {ECO:0000250|UniProtKB:I6YC53}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:I6YC53}.
CC       Note=Probably secreted via the ESX-4 / type VII secretion system
CC       (T7SS). {ECO:0000250|UniProtKB:I6YC53}.
CC   -!- INDUCTION: Transcriptionally regulated by the sigma factor SigM.
CC       {ECO:0000269|PubMed:17088352}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. ESAT-6 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK47890.1; -; Genomic_DNA.
DR   PIR; B70977; B70977.
DR   RefSeq; WP_003900059.1; NZ_KK341227.1.
DR   AlphaFoldDB; O06261; -.
DR   SMR; O06261; -.
DR   EnsemblBacteria; AAK47890; AAK47890; MT3549.
DR   KEGG; mtc:MT3549; -.
DR   PATRIC; fig|83331.31.peg.3808; -.
DR   HOGENOM; CLU_151185_3_4_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
DR   TIGRFAMs; TIGR03930; WXG100_ESAT6; 1.
PE   2: Evidence at transcript level;
KW   Secreted.
FT   CHAIN           1..100
FT                   /note="ESAT-6-like protein EsxT"
FT                   /id="PRO_0000436934"
SQ   SEQUENCE   100 AA;  11120 MW;  5046B1B46578DC6C CRC64;
     MNADPVLSYN FDAIEYSVRQ EIHTTAARFN AALQELRSQI APLQQLWTRE AAAAYHAEQL
     KWHQAASALN EILIDLGNAV RHGADDVAHA DRRAAGAWAR