ID   ESXU_MYCTO              Reviewed;         105 AA.
AC   Q7D5J1;
DT   07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
DT   07-SEP-2016, sequence version 2.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=ESAT-6-like protein EsxU {ECO:0000250|UniProtKB:I6Y3I6};
GN   Name=esxU {ECO:0000303|PubMed:17088352};
GN   OrderedLocusNames=MT3550 {ECO:0000312|EMBL:AAK47891.1};
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
RN   [2]
RP   INDUCTION.
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=17088352; DOI=10.1128/iai.01395-06;
RA   Agarwal N., Woolwine S.C., Tyagi S., Bishai W.R.;
RT   "Characterization of the Mycobacterium tuberculosis sigma factor SigM by
RT   assessment of virulence and identification of SigM-dependent genes.";
RL   Infect. Immun. 75:452-461(2007).
CC   -!- SUBUNIT: Forms a tight 1:1 complex with EsxT.
CC       {ECO:0000250|UniProtKB:I6Y3I6}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:I6Y3I6}.
CC       Note=Probably secreted via the ESX-4 / type VII secretion system
CC       (T7SS). {ECO:0000250|UniProtKB:I6Y3I6}.
CC   -!- INDUCTION: Transcriptionally regulated by the sigma factor SigM.
CC       {ECO:0000269|PubMed:17088352}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. CFP-10 subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK47891.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK47891.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_003900060.1; NZ_KK341227.1.
DR   AlphaFoldDB; Q7D5J1; -.
DR   SMR; Q7D5J1; -.
DR   EnsemblBacteria; AAK47891; AAK47891; MT3550.
DR   GeneID; 45427435; -.
DR   KEGG; mtc:MT3550; -.
DR   PATRIC; fig|83331.31.peg.3809; -.
DR   HOGENOM; CLU_165460_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
PE   2: Evidence at transcript level;
KW   Secreted.
FT   CHAIN           1..105
FT                   /note="ESAT-6-like protein EsxU"
FT                   /id="PRO_0000436936"
SQ   SEQUENCE   105 AA;  11434 MW;  EBE82C2538F37092 CRC64;
     MSTPNTLNAD FDLMRSVAGI TDARNEEIRA MLQAFIGRMS GVPPSVWGGL AAARFQDVVD
     RWNAESTRLY HVLHAIADTI RHNEAALREA GQIHARHIAA AGGDL