ID   ESXW_MYCTU              Reviewed;          98 AA.
AC   P9WNI3; L0TD27; O07932;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=ESAT-6-like protein EsxW {ECO:0000305};
GN   Name=esxW {ECO:0000303|PubMed:19876390}; OrderedLocusNames=Rv3620c;
GN   ORFNames=MTCY07H7B.02, MTCY15C10.32;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   STRAIN=ATCC 27294 / TMC 102 / H37Rv;
RX   PubMed=12919853; DOI=10.1016/s1286-4579(03)00179-5;
RA   He X.Y., Zhuang Y.H., Zhang X.G., Li G.L.;
RT   "Comparative proteome analysis of culture supernatant proteins of
RT   Mycobacterium tuberculosis H37Rv and H37Ra.";
RL   Microbes Infect. 5:851-856(2003).
RN   [3]
RP   NOMENCLATURE.
RX   PubMed=19876390; DOI=10.1371/journal.ppat.1000507;
RA   Bitter W., Houben E.N., Bottai D., Brodin P., Brown E.J., Cox J.S.,
RA   Derbyshire K., Fortune S.M., Gao L.Y., Liu J., Gey van Pittius N.C.,
RA   Pym A.S., Rubin E.J., Sherman D.R., Cole S.T., Brosch R.;
RT   "Systematic genetic nomenclature for type VII secretion systems.";
RL   PLoS Pathog. 5:E1000507-E1000507(2009).
RN   [4]
RP   INTERACTION WITH ESXV, AND SUBCELLULAR LOCATION.
RC   STRAIN=H37Rv;
RX   PubMed=21134129; DOI=10.1111/j.1742-4658.2010.07958.x;
RA   Mahmood A., Srivastava S., Tripathi S., Ansari M.A., Owais M., Arora A.;
RT   "Molecular characterization of secretory proteins Rv3619c and Rv3620c from
RT   Mycobacterium tuberculosis H37Rv.";
RL   FEBS J. 278:341-353(2011).
CC   -!- SUBUNIT: Forms a tight 1:1 complex with EsxV. The complex is
CC       destabilized at low pH. Unfolding of the proteins is required for
CC       dissociation of the complex and membrane binding.
CC       {ECO:0000269|PubMed:21134129}.
CC   -!- INTERACTION:
CC       P9WNI3; P9WNK1: Rv3619c; NbExp=2; IntAct=EBI-8531788, EBI-8531756;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12919853}.
CC       Note=Probably secreted via the ESX-5 / type VII secretion system (T7SS)
CC       (Probable). May bind to lipid membranes after dissociation of the
CC       complex (Probable). {ECO:0000305|PubMed:19876390,
CC       ECO:0000305|PubMed:21134129}.
CC   -!- SIMILARITY: Belongs to the WXG100 family. CFP-10 subfamily.
CC       {ECO:0000305|PubMed:19876390}.
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DR   EMBL; AL123456; CCP46443.1; -; Genomic_DNA.
DR   PIR; E70560; E70560.
DR   RefSeq; NP_218137.1; NC_000962.3.
DR   RefSeq; WP_003899603.1; NZ_KK339374.1.
DR   AlphaFoldDB; P9WNI3; -.
DR   SMR; P9WNI3; -.
DR   IntAct; P9WNI3; 1.
DR   MINT; P9WNI3; -.
DR   STRING; 83332.Rv3620c; -.
DR   PaxDb; P9WNI3; -.
DR   GeneID; 885787; -.
DR   KEGG; mtu:Rv3620c; -.
DR   TubercuList; Rv3620c; -.
DR   eggNOG; COG4842; Bacteria.
DR   OMA; MWASSTN; -.
DR   PhylomeDB; P9WNI3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036689; ESAT-6-like_sf.
DR   InterPro; IPR010310; T7SS_ESAT-6-like.
DR   Pfam; PF06013; WXG100; 1.
DR   SUPFAM; SSF140453; SSF140453; 1.
DR   TIGRFAMs; TIGR03930; WXG100_ESAT6; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Secreted.
FT   CHAIN           1..98
FT                   /note="ESAT-6-like protein EsxW"
FT                   /id="PRO_0000167816"
SQ   SEQUENCE   98 AA;  11023 MW;  137B210CBFCAD2A1 CRC64;
     MTSRFMTDPH AMRDMAGRFE VHAQTVEDEA RRMWASAQNI SGAGWSGMAE ATSLDTMTQM
     NQAFRNIVNM LHGVRDGLVR DANNYEQQEQ ASQQILSS