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ETC2_ARATH
ID   ETC2_ARATH              Reviewed;         112 AA.
AC   Q84RD1; O04349;
DT   24-JUL-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=MYB-like transcription factor ETC2;
DE   AltName: Full=Protein ENHANCER OF TRY AND CPC 2;
GN   Name=ETC2; OrderedLocusNames=At2g30420; ORFNames=T6B20, T9D9;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=cv. Columbia, cv. Edi-0, cv. Hi-0, cv. Ita, cv. Lim, cv. Mh-0,
RC   cv. Pog-0, and cv. Wassilewskija;
RX   PubMed=19818620; DOI=10.1016/j.cub.2009.08.057;
RA   Hilscher J., Schlotterer C., Hauser M.T.;
RT   "A single amino acid replacement in ETC2 shapes trichome patterning in
RT   natural Arabidopsis populations.";
RL   Curr. Biol. 19:1747-1751(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Qu L., Gu H.;
RT   "The MYB transcription factor family in Arabidopsis: a genome-wide cloning
RT   and expression pattern analysis.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=12481096; DOI=10.1104/pp.010207;
RA   Xiao Y.-L., Malik M., Whitelaw C.A., Town C.D.;
RT   "Cloning and sequencing of cDNAs for hypothetical genes from chromosome 2
RT   of Arabidopsis.";
RL   Plant Physiol. 130:2118-2128(2002).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA   Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   FUNCTION, INTERACTION WITH GL3, AND TISSUE SPECIFICITY.
RX   PubMed=15604688; DOI=10.1007/s11103-004-0893-8;
RA   Kirik V., Simon M., Wester K., Schiefelbein J., Hulskamp M.;
RT   "ENHANCER of TRY and CPC 2 (ETC2) reveals redundancy in the region-specific
RT   control of trichome development of Arabidopsis.";
RL   Plant Mol. Biol. 55:389-398(2004).
CC   -!- FUNCTION: MYB-type transcription factor involved in epidermal cell fate
CC       specification. Acts as a negative regulator of trichome development, by
CC       mediating lateral inhibition. Promotes the formation of hair developing
CC       cells in H position in root epidermis, probably by inhibiting non-hair
CC       cell formation. {ECO:0000269|PubMed:15604688,
CC       ECO:0000269|PubMed:19818620}.
CC   -!- SUBUNIT: Interacts with GL3. {ECO:0000269|PubMed:15604688}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in stomatal guard mother cells, young
CC       stomata and trichomes of young leaves, and inflorescences.
CC       {ECO:0000269|PubMed:15604688}.
CC   -!- MISCELLANEOUS: Overexpression of ETC2 results in the suppression of
CC       trichomes and overproduction of root hairs, as observed for CPC, TRY,
CC       ETC1 and ETC3 (PubMed:15604688). In natural Arabidopsis populations the
CC       single amino acid substitution of Lys-19 to Glu might affect the
CC       stability of the ETC2 repressor and causes reduced trichome number
CC       (PubMed:19818620). {ECO:0000305|PubMed:15604688,
CC       ECO:0000305|PubMed:19818620}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB63092.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AAM14822.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AY519520; AAS09990.1; -; mRNA.
DR   EMBL; FJ972635; ADC68265.1; -; Genomic_DNA.
DR   EMBL; FJ972636; ADC68266.1; -; Genomic_DNA.
DR   EMBL; FJ972639; ADC68269.1; -; Genomic_DNA.
DR   EMBL; FJ972640; ADC68270.1; -; Genomic_DNA.
DR   EMBL; FJ972646; ADC68276.1; -; Genomic_DNA.
DR   EMBL; FJ972648; ADC68278.1; -; Genomic_DNA.
DR   EMBL; FJ972649; ADC68279.1; -; Genomic_DNA.
DR   EMBL; FJ972651; ADC68281.1; -; Genomic_DNA.
DR   EMBL; FJ972652; ADC68282.1; -; Genomic_DNA.
DR   EMBL; FJ972653; ADC68283.1; -; Genomic_DNA.
DR   EMBL; AC002338; AAM14822.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; U93215; AAB63092.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002685; AEC08385.1; -; Genomic_DNA.
DR   EMBL; AY234411; AAO92055.1; -; mRNA.
DR   EMBL; AY649255; AAT69172.1; -; mRNA.
DR   PIR; C84708; C84708.
DR   RefSeq; NP_850145.1; NM_179814.4.
DR   AlphaFoldDB; Q84RD1; -.
DR   SMR; Q84RD1; -.
DR   BioGRID; 2942; 11.
DR   IntAct; Q84RD1; 12.
DR   STRING; 3702.AT2G30420.1; -.
DR   PaxDb; Q84RD1; -.
DR   PRIDE; Q84RD1; -.
DR   EnsemblPlants; AT2G30420.1; AT2G30420.1; AT2G30420.
DR   GeneID; 817593; -.
DR   Gramene; AT2G30420.1; AT2G30420.1; AT2G30420.
DR   KEGG; ath:AT2G30420; -.
DR   Araport; AT2G30420; -.
DR   TAIR; locus:2064352; AT2G30420.
DR   HOGENOM; CLU_178021_1_0_1; -.
DR   InParanoid; Q84RD1; -.
DR   OMA; NEIERYW; -.
DR   OrthoDB; 1531077at2759; -.
DR   PhylomeDB; Q84RD1; -.
DR   PRO; PR:Q84RD1; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q84RD1; baseline and differential.
DR   Genevisible; Q84RD1; AT.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:1900033; P:negative regulation of trichome patterning; IMP:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR   GO; GO:0080147; P:root hair cell development; IMP:UniProtKB.
DR   GO; GO:0048629; P:trichome patterning; IMP:TAIR.
DR   CDD; cd00167; SANT; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR001005; SANT/Myb.
DR   Pfam; PF00249; Myb_DNA-binding; 1.
DR   SMART; SM00717; SANT; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..112
FT                   /note="MYB-like transcription factor ETC2"
FT                   /id="PRO_0000423053"
FT   DOMAIN          41..78
FT                   /note="Myb-like"
SQ   SEQUENCE   112 AA;  13605 MW;  C7C86DDF9E5A4873 CRC64;
     MDNTNRLRLR RGPSLRQTKF TRSRYDSEEV SSIEWEFISM TEQEEDLISR MYRLVGNRWD
     LIAGRVVGRK ANEIERYWIM RNSDYFSHKR RRLNNSPFFS TSPLNLQENL KL
 
 
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