ETC3_ARATH
ID ETC3_ARATH Reviewed; 75 AA.
AC Q9M157; Q8GXU0;
DT 24-JUL-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 142.
DE RecName: Full=MYB-like transcription factor ETC3;
DE AltName: Full=Protein CAPRICE-like MYB3;
DE AltName: Full=Protein ENHANCER OF TRY AND CPC 3;
GN Name=ETC3; Synonyms=CPL3; OrderedLocusNames=At4g01060; ORFNames=F2N1.40;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Qu L., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: a genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Tominaga R., Wada T.;
RT "Small Myb is involved in the determination of epidermal cell fate.";
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [7]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=18305006; DOI=10.1242/dev.017947;
RA Tominaga R., Iwata M., Sano R., Inoue K., Okada K., Wada T.;
RT "Arabidopsis CAPRICE-LIKE MYB 3 (CPL3) controls endoreduplication and
RT flowering development in addition to trichome and root hair formation.";
RL Development 135:1335-1345(2008).
CC -!- FUNCTION: MYB-type transcription factor involved in epidermal cell fate
CC specification. Acts as a negative regulator of trichome development,
CC including endoreplication, by mediating lateral inhibition. Promotes
CC the formation of hair developing cells in H position in root epidermis,
CC probably by inhibiting non-hair cell formation. May have pleiotropic
CC effects on flowering development and epidermal cell size through the
CC regulation of endoreduplication. {ECO:0000269|PubMed:18305006}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9M157-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9M157-2; Sequence=VSP_047516;
CC -!- TISSUE SPECIFICITY: Expressed in leaf epidermal cells, stomate guard
CC cells in leaves, cotyledons and hypocotyls, inflorescences, developing
CC seeds and siliques. {ECO:0000269|PubMed:18305006}.
CC -!- DISRUPTION PHENOTYPE: Increased number or trichomes and reduced number
CC of root hairs. {ECO:0000269|PubMed:18305006}.
CC -!- MISCELLANEOUS: Overexpression of ETC3 results in the suppression of
CC trichomes and overproduction of root hairs, as observed for CPC, TRY,
CC ETC1 and ETC2. {ECO:0000305|PubMed:18305006}.
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DR EMBL; AY519522; AAS09992.1; -; mRNA.
DR EMBL; AB264292; BAF43577.1; -; mRNA.
DR EMBL; AL161491; CAB80915.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE81974.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE81976.1; -; Genomic_DNA.
DR EMBL; AK118043; BAC42674.1; -; mRNA.
DR EMBL; BT005611; AAO64031.1; -; mRNA.
DR PIR; A85014; A85014.
DR RefSeq; NP_001031567.1; NM_001036490.2. [Q9M157-1]
DR RefSeq; NP_192015.2; NM_116336.4. [Q9M157-2]
DR AlphaFoldDB; Q9M157; -.
DR SMR; Q9M157; -.
DR BioGRID; 13208; 9.
DR IntAct; Q9M157; 9.
DR STRING; 3702.AT4G01060.1; -.
DR PaxDb; Q9M157; -.
DR EnsemblPlants; AT4G01060.1; AT4G01060.1; AT4G01060. [Q9M157-2]
DR EnsemblPlants; AT4G01060.3; AT4G01060.3; AT4G01060. [Q9M157-1]
DR GeneID; 827917; -.
DR Gramene; AT4G01060.1; AT4G01060.1; AT4G01060. [Q9M157-2]
DR Gramene; AT4G01060.3; AT4G01060.3; AT4G01060. [Q9M157-1]
DR KEGG; ath:AT4G01060; -.
DR Araport; AT4G01060; -.
DR TAIR; locus:2125008; AT4G01060.
DR OMA; MENHLMT; -.
DR OrthoDB; 1531077at2759; -.
DR PhylomeDB; Q9M157; -.
DR PRO; PR:Q9M157; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9M157; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0048765; P:root hair cell differentiation; IMP:TAIR.
DR GO; GO:0010026; P:trichome differentiation; IMP:TAIR.
DR GO; GO:0010228; P:vegetative to reproductive phase transition of meristem; IMP:TAIR.
DR CDD; cd00167; SANT; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Developmental protein; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..75
FT /note="MYB-like transcription factor ETC3"
FT /id="PRO_0000423054"
FT DOMAIN 34..71
FT /note="Myb-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00133"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 21
FT /note="E -> EGT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11910074,
FT ECO:0000303|PubMed:14593172, ECO:0000303|Ref.2"
FT /id="VSP_047516"
SQ SEQUENCE 75 AA; 8743 MW; 3FB63D5C5C3B3E61 CRC64;
MDNHRRTKQP KTNSIVTSSS EEVSSLEWEV VNMSQEEEDL VSRMHKLVGD RWELIAGRIP
GRTAGEIERF WVMKN
