ID   ETC76_ENTSX             Reviewed;          62 AA.
AC   P85147;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Enterocin E-760;
DE   AltName: Full=Bacteriocin E-760;
OS   Enterococcus sp.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=35783;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR
RP   LOCATION, AND MASS SPECTROMETRY.
RC   STRAIN=NRRL B-30745 {ECO:0000269|PubMed:18086839};
RX   PubMed=18086839; DOI=10.1128/aac.01569-06;
RA   Line J.E., Svetoch E.A., Eruslanov B.V., Perelygin V.V., Mitsevich E.V.,
RA   Mitsevich I.P., Levchuk V.P., Svetoch O.E., Seal B., Siragusa G.,
RA   Stern N.J.;
RT   "Isolation and purification of enterocin E-760 with broad antimicrobial
RT   activity against Gram-positive and Gram-negative bacteria.";
RL   Antimicrob. Agents Chemother. 52:1094-1100(2008).
CC   -!- FUNCTION: Bacteriocin active against the Gram-negative bacteria
CC       S.enteritidis, S.choleraesuis, S.typhimurium, S.gallinarum, E.coli
CC       O157:H7, Y.enterocolitica, C.freundii, K.pneumoniae, S.dysentriae,
CC       P.aeruginosa, P.mirabilis, M.morganii, C.jejuni and 20 other
CC       Campylobacter isolates, and the Gram-positive bacteria S.aureus,
CC       S.epidermidis and L.monocytogenes. {ECO:0000269|PubMed:18086839}.
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       pH dependence:
CC         Stable between pH 5.0 and pH 8.7. Activity is lost at pH 3.0 and
CC         above pH 9.5. {ECO:0000269|PubMed:18086839};
CC       Temperature dependence:
CC         Thermostable, retains activity after heating at 100 degrees Celsius
CC         for 5 minutes. {ECO:0000269|PubMed:18086839};
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18086839}.
CC   -!- MASS SPECTROMETRY: Mass=5362; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:18086839};
CC   -!- SIMILARITY: Belongs to the bacteriocin class IIB family. {ECO:0000255}.
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DR   AlphaFoldDB; P85147; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Bacteriocin; Direct protein sequencing;
KW   Secreted.
FT   CHAIN           1..62
FT                   /note="Enterocin E-760"
FT                   /id="PRO_0000320547"
SQ   SEQUENCE   62 AA;  6180 MW;  D581FCBFD516AFBD CRC64;
     NRWYCNSAAG GVGGAAVCGL AGYVGEAKEN IAGEVRKGWG MAGGFTHNKA CKSFPGSGWA
     SG