ID   ETF1_YMTV5              Reviewed;         635 AA.
AC   Q9QB97;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Early transcription factor 70 kDa subunit;
DE            EC=3.6.4.-;
DE   AltName: Full=ATP-dependent helicase VETFS;
DE   AltName: Full=VETF small subunit;
GN   Name=VETFS; OrderedLocusNames=84R; ORFNames=B1R;
OS   Yaba monkey tumor virus (strain VR587) (YMTV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Yatapoxvirus.
OX   NCBI_TaxID=928314;
OH   NCBI_TaxID=9538; Erythrocebus patas (Red guenon) (Cercopithecus patas).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9539; Macaca (macaques).
OH   NCBI_TaxID=9557; Papio hamadryas (Hamadryas baboon).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14645589; DOI=10.1128/jvi.77.24.13335-13347.2003;
RA   Brunetti C.R., Amano H., Ueda Y., Qin J., Miyamura T., Suzuki T., Li X.,
RA   Barrett J.W., McFadden G.;
RT   "Complete genomic sequence and comparative analysis of the tumorigenic
RT   poxvirus Yaba monkey tumor virus.";
RL   J. Virol. 77:13335-13347(2003).
CC   -!- FUNCTION: Acts with RNA polymerase to initiate transcription from early
CC       gene promoters. A DNA-dependent ATPase activity is associated with
CC       VETF.
CC   -!- SUBUNIT: Heterodimer of a 70 kDa and a 82 kDa subunit.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Note=All the enzymes and
CC       other proteins required to synthesize early mRNAs are packaged within
CC       the virion core along with the DNA genome. This is necessary because
CC       viral early mRNAs are synthesized within minutes after virus entry into
CC       the cell and are extruded through pores in the core particle.
CC   -!- SIMILARITY: Belongs to the helicase family. VETF subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AY386371; AAR07440.1; -; Genomic_DNA.
DR   RefSeq; NP_938339.1; NC_005179.1.
DR   SMR; Q9QB97; -.
DR   GeneID; 2943669; -.
DR   KEGG; vg:2943669; -.
DR   Proteomes; UP000008596; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   Activator; ATP-binding; Helicase; Hydrolase; Nucleotide-binding;
KW   Reference proteome; Transcription; Transcription regulation; Virion.
FT   CHAIN           1..635
FT                   /note="Early transcription factor 70 kDa subunit"
FT                   /id="PRO_0000099078"
FT   DOMAIN          32..185
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          326..505
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   MOTIF           135..138
FT                   /note="DEXH box"
FT   BINDING         45..52
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   635 AA;  73290 MW;  BFD459B55A1D1854 CRC64;
     MNLEIVDLFN GHVNSIPNIL PHQLATLDYL VRSIIDENKS VLLFHIMGSG KTIIALLFAL
     VASRFKKVYI LVPNINILKI FNYSMDVAIN LFNSEYILEN IFIHSTTSFY SLNYNDNVIN
     YNGLSRYNNA IFIIDEAHNI FGNNTGELMT VIKNKNKIPF LLLSGSPITN TPITLSNIIS
     LMSDENINFG DIIIQGKKVF QILLNENGVN VLKNILKGRI SYYEMPSTDL PKVQYHGKKF
     LDTRVVYCHM SKLQEKDYNN VRKLCNNEMF EKNMNNVSLA VLGQLNFINN LDILFQEQDK
     ELYPNLKISN GILYGDELTT LNISSKFKYF IGKITSLTGK QFIYFSNSTY GGLIIKYIML
     SNGYSEYNGS QGTNPKLING KPKTFAIVTS KMKSSLEDLL NVYNSQLNKD GSQIMFLFSS
     NIMSESYTLK EVRNIWFMTI PDTFSQYNQI LGRSIRKFSY FDISKPVNVY LLATVYADFD
     DDITSLEDYS LDEINTLPFD IKKLLYLKFK TKETNRIYSI LQNISDTYRM PPHPYIVELV
     LGEIVRQFFY HHSRISFDSK ELINAIQLVL PNIDMAKKYI NEVVNGHFFV SNKVFDKSLL
     YRYKNDIITV PFKLSHERFV WGVNFRKEYN VVSSP