ID   ETF2_FOWPN              Reviewed;         709 AA.
AC   Q9J562;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Early transcription factor 82 kDa subunit;
DE   AltName: Full=ETF large subunit;
GN   Name=VETFL; OrderedLocusNames=FPV171;
OS   Fowlpox virus (strain NVSL) (FPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Avipoxvirus.
OX   NCBI_TaxID=928301;
OH   NCBI_TaxID=7742; Vertebrata.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10729156; DOI=10.1128/jvi.74.8.3815-3831.2000;
RA   Afonso C.L., Tulman E.R., Lu Z., Zsak L., Kutish G.F., Rock D.L.;
RT   "The genome of fowlpox virus.";
RL   J. Virol. 74:3815-3831(2000).
CC   -!- FUNCTION: Acts with RNA polymerase to initiate transcription from early
CC       gene promoters. Is recruited by the RPO-associated protein of 94 kDa
CC       (RAP94) to form the early transcription complex, which also contains
CC       the core RNA polymerase. ETF heterodimer binds to early gene promoters
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of a 70 kDa and a 82 kDa subunit. Part of the
CC       early transcription complex composed of ETF, RAP94, and the DNA-
CC       directed RNA polymerase (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=All the enzymes and
CC       other proteins required to synthesize early mRNAs are packaged within
CC       the virion core along with the DNA genome. This is necessary because
CC       viral early mRNAs are synthesized within minutes after virus entry into
CC       the cell and are extruded through pores in the core particle (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae VETF large subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AF198100; AAF44515.1; -; Genomic_DNA.
DR   RefSeq; NP_039134.1; NC_002188.1.
DR   SMR; Q9J562; -.
DR   PRIDE; Q9J562; -.
DR   GeneID; 1486719; -.
DR   KEGG; vg:1486719; -.
DR   Proteomes; UP000008597; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR007532; Poxvirus_early-TF_lsu.
DR   Pfam; PF04441; Pox_VERT_large; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation; Virion.
FT   CHAIN           1..709
FT                   /note="Early transcription factor 82 kDa subunit"
FT                   /id="PRO_0000099084"
SQ   SEQUENCE   709 AA;  82730 MW;  79C39E93A84E051C CRC64;
     MYVVNPQLVV LVDKDQEILD VLYLTLYDGI DERSSMYYFI KNHLRVPMDR VRVLKKHIIL
     TLKISQVKGY ICDLLNIDEE IIIYSHKNNL EYSYVDNTTF NPFTMTQRKT LLKSKSFLYN
     VYVDACNFLV IWVAKAADTM VKELGSYEEV DANVLKFESR LIEMFPDLDL DFTVESKFNN
     VFRTNLKMTG LKNIVLSNTD KKILFIKSDE YFINLSGNHF VINDESLNLS IWDDDGSLAI
     SSDGNTITVN NVKLFTDMIP NNNVQMERIK SDITYKVKLS TPITSKVKLD IETSFIFIET
     ATNNILLSVD KKISIILAKN HISIKVKNHI PNIEKYFTFL VVFINRLFNT VKQSMDFTKI
     ETIYWSRICQ NTKDKNRKPV IISSLEPDML KVSDNFYKSP TKEVFVNNNE VMFTCDDKTG
     KYNNIGFLAI FYKLQKICIP CCFLKNQSHT DTFMACVHNK QTDKNIISPY ILNYGKVVTD
     SKIAFLPPIF NDFFNSDLSI SLESDNKRLK STKGYHVIRS CLHNCRYYTL KRIRTKNDII
     QFVNTENVTL IANDIVYFPM KYSSINNKIY ILVQEIVHEI VIAKKEEDKD MIYFEELRTN
     KLRDMFPYKV KTVDIKEQNG LKLTTDGFYV DGELFTEPLS TKRSVFMDNI STQNNPIVKY
     FNSVFKYVVT DNKEIFIKTW VINTMLKLGI GKDYTHIQIK SILEKYYKL