ID   ETF2_MCV1               Reviewed;         707 AA.
AC   Q98277;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   29-SEP-2021, entry version 72.
DE   RecName: Full=Early transcription factor 82 kDa subunit;
DE   AltName: Full=ETF large subunit;
GN   Name=VETFL; OrderedLocusNames=MC110L;
OS   Molluscum contagiosum virus subtype 1 (MOCV) (MCVI).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Molluscipoxvirus.
OX   NCBI_TaxID=10280;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8670425; DOI=10.1126/science.273.5276.813;
RA   Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., Moss B.;
RT   "Genome sequence of a human tumorigenic poxvirus: prediction of specific
RT   host response-evasion genes.";
RL   Science 273:813-816(1996).
CC   -!- FUNCTION: Acts with RNA polymerase to initiate transcription from early
CC       gene promoters. Is recruited by the RPO-associated protein of 94 kDa
CC       (RAP94) to form the early transcription complex, which also contains
CC       the core RNA polymerase. ETF heterodimer binds to early gene promoters
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of a 70 kDa and a 82 kDa subunit. Part of the
CC       early transcription complex composed of ETF, RAP94, and the DNA-
CC       directed RNA polymerase (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=All the enzymes and
CC       other proteins required to synthesize early mRNAs are packaged within
CC       the virion core along with the DNA genome. This is necessary because
CC       viral early mRNAs are synthesized within minutes after virus entry into
CC       the cell and are extruded through pores in the core particle (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae VETF large subunit family.
CC       {ECO:0000305}.
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DR   EMBL; U60315; AAC55238.1; -; Genomic_DNA.
DR   PIR; T30712; T30712.
DR   RefSeq; NP_044061.1; NC_001731.1.
DR   SMR; Q98277; -.
DR   GeneID; 1487129; -.
DR   KEGG; vg:1487129; -.
DR   Proteomes; UP000000869; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR007532; Poxvirus_early-TF_lsu.
DR   Pfam; PF04441; Pox_VERT_large; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation; Virion.
FT   CHAIN           1..707
FT                   /note="Early transcription factor 82 kDa subunit"
FT                   /id="PRO_0000099085"
SQ   SEQUENCE   707 AA;  82104 MW;  FF9C1DE00CC52AE3 CRC64;
     MYTVNPQLVV LVDRQQQLRE VRYLSLYGTL DEASPLYYFA KQHLRAETLA VERRHILLTL
     KISQLKGYLC HLLGLREDII IYSHKNNLEY SYVDNTIFNP FTMTQKKTLI KADSFLYNVY
     VDACDFLVVW VARAQDTPVP EFGSFEEVDA NILKFEARLV EMFPELDLEF SIQSKFNNVF
     RTNLRSTGLR NIVKRNQDNR ILFIKTDEFF ITMSGNHFVL NNEALNLSIW DAQGRLAISS
     DGDTITVNDV RLFTELVTDS NLQMERIKGD ITYRIFLLSP ITSKIKLDIE TSFIFVETAT
     NNILLSADKK ISIILAKNHI SIKVKNHIPN IEKYFTFLVI FINRMFNAVQ QAVDFTKIET
     IYWSRICQNT RDKNRKPVIV SSLDANMERV SDNFFRSPTR EVFVNSNNIM FSCVDPLGKY
     NSVGFLAIFY KLQKMCIPCC FLRSQAHTDT FISCVHHREL DRQLVSPYVL NFGKIVTEAK
     ISFLPILFDQ FFNEGLRIEF EADHKRLKAT DGYHVVKCCT RSEITRLRTQ RDIIQFVNAE
     QNTLIAGDMV YFPMHGARSA GAEHQRVYIL IQEIVHEVVM VQKAHDSDRI RFRELERNRL
     WEFFPYRVPS ARIKEEHGLV LTTDGFYVDG KLFSEPLSTR YVAFTENVGT AGVAAKYFAP
     VFKYVVTEAR ELFIKTWLLN VMMQLGLTGE SSAAQTREAL ERYYRLS