ID   ETF2_MYXVL              Reviewed;         711 AA.
AC   Q9Q8K4;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   29-SEP-2021, entry version 65.
DE   RecName: Full=Early transcription factor 82 kDa subunit;
DE   AltName: Full=ETF large subunit;
GN   Name=VETFL; OrderedLocusNames=m096L;
OS   Myxoma virus (strain Lausanne) (MYXV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Leporipoxvirus.
OX   NCBI_TaxID=31530;
OH   NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10562494; DOI=10.1006/viro.1999.0001;
RA   Cameron C., Hota-Mitchell S., Chen L., Barrett J.W., Cao J.-X.,
RA   Macaulay C., Willer D.O., Evans D.H., McFadden G.;
RT   "The complete DNA sequence of myxoma virus.";
RL   Virology 264:298-318(1999).
CC   -!- FUNCTION: Acts with RNA polymerase to initiate transcription from early
CC       gene promoters. Is recruited by the RPO-associated protein of 94 kDa
CC       (RAP94) to form the early transcription complex, which also contains
CC       the core RNA polymerase. ETF heterodimer binds to early gene promoters
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of a 70 kDa and a 82 kDa subunit. Part of the
CC       early transcription complex composed of ETF, RAP94, and the DNA-
CC       directed RNA polymerase (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=All the enzymes and
CC       other proteins required to synthesize early mRNAs are packaged within
CC       the virion core along with the DNA genome. This is necessary because
CC       viral early mRNAs are synthesized within minutes after virus entry into
CC       the cell and are extruded through pores in the core particle (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae VETF large subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AF170726; AAF14984.1; -; Genomic_DNA.
DR   RefSeq; NP_051810.1; NC_001132.2.
DR   SMR; Q9Q8K4; -.
DR   GeneID; 932176; -.
DR   KEGG; vg:932176; -.
DR   Proteomes; UP000000867; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR007532; Poxvirus_early-TF_lsu.
DR   Pfam; PF04441; Pox_VERT_large; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation; Virion.
FT   CHAIN           1..711
FT                   /note="Early transcription factor 82 kDa subunit"
FT                   /id="PRO_0000099087"
SQ   SEQUENCE   711 AA;  82688 MW;  F69EC4F63B087E61 CRC64;
     MRYVVNPQLV LYVEKGQKIK RALYLTPYGT LDDKSPIYYF LSTHLKITDP EVHKRHILLT
     LKISQLKGYL CDLLRIRNDV IIYSHKNNLE YSYVDNTIFN PFAHTQKKTL IKSDGFLYNI
     YPDACDFLVI WVADAEDTSI AEFGSYEDVD VNILKFETRL LEVFDDLDLD MTIESKFNNI
     FRTNLKFTGL RKLIKKINEF NGSRYKSLLY KSDEYFINLT GNKFILTDER LNLTVWDSDG
     VVTFSSDGDT IMINNVKLFT SLLTDIDLQM ERIKGDVTYK IFLSTPITSR IKLNIETSFI
     FVETATNNIL LSADKRISII LAKNHISIKV KNYIPNIEKY FTFLVIAINS MFNNIQQASD
     FTKVETVYWS RICQNTKNKH RKPVIVSSLD EDMEKVSDNF YKSSTKEVFI NSSGIMFSCL
     DPLNKYNYVG FLSIFYRLQK MCIPCCFLKN QSHTETFSSC VYQKEIASDV INPYILNFGK
     VVTKSKISFL PIIFDSFFNE GVKIIFEQDN KRLKETIGYH VIKSCDEDIK RLRTISDIIA
     FVNEDKNILI AEDIIYFPMN YVDIGTRVYI LIQEIVHEIV VVKKHMSKDA IEVFPPNYKL
     VKNLFPRQTK FITIRSDSGM ELTTDGFLVD GKEFNVDLSS NYVAFTKNIT TPYTLSKYFS
     PLFKYAITES KNRFMKTWLI NTMLRLGIDL DLDTNILPKL EKYYPNHGKS V