ID   ETF2_RFVKA              Reviewed;         711 AA.
AC   Q9Q8Y2;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   02-DEC-2020, entry version 59.
DE   RecName: Full=Early transcription factor 82 kDa subunit;
DE   AltName: Full=ETF large subunit;
GN   Name=VETFL; OrderedLocusNames=s096L;
OS   Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain
OS   Kasza)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Leporipoxvirus.
OX   NCBI_TaxID=10272;
OH   NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10562495; DOI=10.1006/viro.1999.0002;
RA   Willer D.O., McFadden G., Evans D.H.;
RT   "The complete genome sequence of shope (Rabbit) fibroma virus.";
RL   Virology 264:319-343(1999).
CC   -!- FUNCTION: Acts with RNA polymerase to initiate transcription from early
CC       gene promoters. Is recruited by the RPO-associated protein of 94 kDa
CC       (RAP94) to form the early transcription complex, which also contains
CC       the core RNA polymerase. ETF heterodimer binds to early gene promoters
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of a 70 kDa and a 82 kDa subunit. Part of the
CC       early transcription complex composed of ETF, RAP94, and the DNA-
CC       directed RNA polymerase (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae VETF large subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AF170722; AAF17979.1; -; Genomic_DNA.
DR   RefSeq; NP_051985.1; NC_001266.1.
DR   SMR; Q9Q8Y2; -.
DR   PRIDE; Q9Q8Y2; -.
DR   GeneID; 1486940; -.
DR   KEGG; vg:1486940; -.
DR   Proteomes; UP000000868; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR007532; Poxvirus_early-TF_lsu.
DR   Pfam; PF04441; Pox_VERT_large; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..711
FT                   /note="Early transcription factor 82 kDa subunit"
FT                   /id="PRO_0000099088"
SQ   SEQUENCE   711 AA;  82649 MW;  07A1C0763176F77B CRC64;
     MRYVVSPQLV LYVEKGQKIK RVLYLTPYGV LDDKSPIYYF LSTHLKITDP EIHRRHILLT
     LKISQLKGYL CNLLDIRNDI IIYSHKNNLE YSYVDNTIFN PFVHTQKKTL IKSDGFLYNI
     YPGACDFLVI WVANADDTSI AEFGSYEDVD VNILKFETRL LEVFDNLDLD MNIESKFNNI
     FRTNLKFTGL RKLIKKINEL NGLYYKSLLY KSDEYFINLT GNKFILTDER LNLTVWDPDG
     VVTFSSDGDT ITINNVKLFT SLLTDIDLQM ERIKGDVTYK IFLSTPITSR IKLNIETSFI
     FVETATNNIL LSADKRISII LAKNHISIKV KNYIPNIEKY FTFLVIAINS MFNNIQQASD
     FTKIETVYWS RICQNTKNKH RKPVIVSSLD DNMEKVSDNF YKSSTKEVFI NSSGIMFSCL
     DPLNKYNYVG FLSIFYRLQK MCIPCCFLKN QSHTETFSSC VHQKEITSDV INPYILNFGK
     VVTKSKISFL PIIFDSFFNK GVKIIFEQDN KRLKETIGYH VVKSCDEDIK RLRTISDIIM
     FVNEDKNILI AEDIIYFPMN YADIGTRVYI LIQEIVHEVI VVKKHMTKDL IEVCPPNYKL
     VKNLFPRQTK FATIRSDSGM ELTTDGFLVD GKEFNVDLSS NYVAFTKNIT TPYTLSKYFA
     PLFKYVITES KNRFMKTWLI NTMLRLGIDL DLDTNILPKL EKYYPNHGKS V