ETF2_VACCT
ID ETF2_VACCT Reviewed; 710 AA.
AC Q9JF93;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 57.
DE RecName: Full=Early transcription factor 82 kDa subunit;
DE AltName: Full=ETF large subunit;
DE AltName: Full=VETF A7 subunit;
DE AltName: Full=Vaccinia virus early transcription factor large subunit;
DE Short=VETF large subunit;
GN Name=VETFL; ORFNames=TA8L;
OS Vaccinia virus (strain Tian Tan) (VACV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX NCBI_TaxID=10253;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Jin Q., Hou Y.D., Cheng N.H., Yao E.M., Cheng S.X., Yang X.K., Jing D.Y.,
RA Yu W.H., Yuan J.S., Ma X.J.;
RT "Complete genomic sequence of vaccinia virus (Tian Tan strain).";
RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts with RNA polymerase to initiate transcription from early
CC gene promoters. Is recruited by the RPO-associated protein of 94 kDa
CC (RAP94) to form the early transcription complex, which also contains
CC the core RNA polymerase. ETF heterodimer binds to early gene promoters
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer of a 70 kDa and a 82 kDa subunit. Part of the
CC early transcription complex composed of ETF, RAP94, and the DNA-
CC directed RNA polymerase (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=All the enzymes and
CC other proteins required to synthesize early mRNAs are packaged within
CC the virion core along with the DNA genome. This is necessary because
CC viral early mRNAs are synthesized within minutes after virus entry into
CC the cell and are extruded through pores in the core particle (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the poxviridae VETF large subunit family.
CC {ECO:0000305}.
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DR EMBL; AF095689; AAF33997.1; -; Genomic_DNA.
DR SMR; Q9JF93; -.
DR Proteomes; UP000163220; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR007532; Poxvirus_early-TF_lsu.
DR Pfam; PF04441; Pox_VERT_large; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Late protein; Transcription;
KW Transcription regulation; Virion.
FT CHAIN 1..710
FT /note="Early transcription factor 82 kDa subunit"
FT /id="PRO_0000099081"
SQ SEQUENCE 710 AA; 82291 MW; 8C19BE5C578C5361 CRC64;
MRYIVSPQLV LQVGKGQEVE RALYLTPYDY IDEKSPIYYF LRSHLNIQQP EIVKRHILLT
LRMTQLKGYL GNLLDIKDDI IIYSHKNNLE YSYVDNTIFN PFVYTQKKTL LKNDSFLYNV
YSGACDFLVI WVARACDTSI PEFGSYEDVD NNIIKFETML MEVFPQLDLD ITVESKFNNI
FRTNLKLTGL KKIIQRVQDL DINYKSLLSR YDEHFINMTG NHFILNDEQL NLSIWDLDGT
LALSSDGDTV MINNVKLFTD LVSDIDTQME RIKGDITYKV HLATPINSRI KLDIETSFIF
IETATNNILL SSDKKISIIL AKNHISIKVK NHIPNIEKYF TFLVIAINAM FNSVQKSADF
TKVETVYWSR ICQNTKNKNR KPIIINYLDP GMKKISNNFY RSDEKEVFIN DNGIMFTCMD
PLGKYNKVGF LNIFHDMRKY CIPCCFLHDQ SHRSTFSSCV HQIDVEKKIV SPYILNFGKV
VTESKMSFLP IIFDAFLNDG MTANMEQDNK RLKETSGYHI VRCCAGDDIV RLRTTSDIIQ
FVNEDKNILI VNDMVYFPMN ASDIGKKIHI LIQEIVHEVM IVKKKESSDK IDFFPPNYKL
LKDLFPKQTI QTPIQSDAGM VLTTDGFYID GKLFNEDLSS KYVTFTKNVI ASDAVAKYFS
PLFKYVISEA KDRFIKTWMI NIMIHMNVDP NNIIPTLEKY YPNSGRAQIN