ID   ETF2_YMTV5              Reviewed;         713 AA.
AC   Q9QB84;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   02-DEC-2020, entry version 69.
DE   RecName: Full=Early transcription factor 82 kDa subunit;
DE   AltName: Full=ETF large subunit;
GN   Name=VETFL; OrderedLocusNames=98L; ORFNames=B14L;
OS   Yaba monkey tumor virus (strain VR587) (YMTV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Yatapoxvirus.
OX   NCBI_TaxID=928314;
OH   NCBI_TaxID=9538; Erythrocebus patas (Red guenon) (Cercopithecus patas).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9539; Macaca (macaques).
OH   NCBI_TaxID=9557; Papio hamadryas (Hamadryas baboon).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14645589; DOI=10.1128/jvi.77.24.13335-13347.2003;
RA   Brunetti C.R., Amano H., Ueda Y., Qin J., Miyamura T., Suzuki T., Li X.,
RA   Barrett J.W., McFadden G.;
RT   "Complete genomic sequence and comparative analysis of the tumorigenic
RT   poxvirus Yaba monkey tumor virus.";
RL   J. Virol. 77:13335-13347(2003).
CC   -!- FUNCTION: Acts with RNA polymerase to initiate transcription from early
CC       gene promoters. Is recruited by the RPO-associated protein of 94 kDa
CC       (RAP94) to form the early transcription complex, which also contains
CC       the core RNA polymerase. ETF heterodimer binds to early gene promoters
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of a 70 kDa and a 82 kDa subunit. Part of the
CC       early transcription complex composed of ETF, RAP94, and the DNA-
CC       directed RNA polymerase (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae VETF large subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AY386371; AAR07454.1; -; Genomic_DNA.
DR   RefSeq; NP_938353.1; NC_005179.1.
DR   SMR; Q9QB84; -.
DR   GeneID; 2943659; -.
DR   KEGG; vg:2943659; -.
DR   Proteomes; UP000008596; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR007532; Poxvirus_early-TF_lsu.
DR   Pfam; PF04441; Pox_VERT_large; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..713
FT                   /note="Early transcription factor 82 kDa subunit"
FT                   /id="PRO_0000099089"
SQ   SEQUENCE   713 AA;  82222 MW;  DD0B8AECE3C3B368 CRC64;
     MKYTISPQLV IYVGKGQEIK RALYLTPYGI LDDKSSIYYF LKTHLNIHNP EIHKRHILLT
     LKIRQVKGYL SNLLNINDDI IIYSHKNNLE FSYVDNTIFN PFTNTQRKTL IRSDGFLYNI
     YPGACDFLVI WVTNSKDTPM LEFGSYEEVD SNILKFENHL LDVFNSLDLE MNIESKFNNI
     FRTNLKSTGL MTIIKKINES DTSYKSLLYK SDEYFINMTG NHFILTDEKL NLSVWDSDSC
     LAFSSDGDTI VINNVKLFTE LVSDINAQME RIKGDVTYKV FLSTPITSRI KLDIETSFVF
     VETATNNILL SADKKISIIL AKNHISIKVK NYIPNIEKYF TFLVVAINSM FNSVQRSSDF
     TKVETVYWSR ICQNTNNKNR KPVIVSSLDV DMKKISNCFY KSKSLEVFIN SNGVMFSCID
     PMGKYNSIGF LSIFYKLQKM CIPCCFLKDQ SHTDTFSSCV YNKDVSNDII SPYILNFGKV
     VTKSKISFLP IIFDSFLNEG LRISFEQDNK RLKETTGYHV VKSCNGDIIR LRTTSDIIAF
     VNDKNTILIA DDIIYFPMNY FSIGNNIYIL VQEIVHEVVL VKKKINKDVI STFSPNSIIL
     RELFPKQTKS VTIRSDSGME LTTDGFLIDG VKFNKDLSSK FMTFTKNVTT SDYISKYFSP
     LFKYVITESK ERFIKTWVIN IMLNFESDVN IESSVIISRL EEYYPNHGKK ITN