ID   ETFA_CAEEL              Reviewed;         332 AA.
AC   Q93615; Q9U5I1;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=Probable electron transfer flavoprotein subunit alpha, mitochondrial;
DE            Short=Alpha-ETF;
DE   Flags: Precursor;
GN   ORFNames=F27D4.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: The electron transfer flavoprotein serves as a specific
CC       electron acceptor for several dehydrogenases, including five acyl-CoA
CC       dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers
CC       the electrons to the main mitochondrial respiratory chain via ETF-
CC       ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity).
CC       {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC       Note=Binds 1 FAD per dimer. {ECO:0000250};
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ETF alpha-subunit/FixB family.
CC       {ECO:0000305}.
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DR   EMBL; Z79695; CAB01967.2; -; Genomic_DNA.
DR   EMBL; Z81130; CAB01967.2; JOINED; Genomic_DNA.
DR   PIR; D87839; D87839.
DR   PIR; T21451; T21451.
DR   RefSeq; NP_492146.1; NM_059745.5.
DR   AlphaFoldDB; Q93615; -.
DR   SMR; Q93615; -.
DR   BioGRID; 37977; 17.
DR   STRING; 6239.F27D4.1; -.
DR   EPD; Q93615; -.
DR   PaxDb; Q93615; -.
DR   PeptideAtlas; Q93615; -.
DR   EnsemblMetazoa; F27D4.1.1; F27D4.1.1; WBGene00009187.
DR   GeneID; 172535; -.
DR   KEGG; cel:CELE_F27D4.1; -.
DR   UCSC; F27D4.1; c. elegans.
DR   CTD; 172535; -.
DR   WormBase; F27D4.1; CE24926; WBGene00009187; -.
DR   eggNOG; KOG3954; Eukaryota.
DR   GeneTree; ENSGT00940000167435; -.
DR   HOGENOM; CLU_034178_0_0_1; -.
DR   InParanoid; Q93615; -.
DR   OMA; WRPYAEQ; -.
DR   OrthoDB; 1128607at2759; -.
DR   PhylomeDB; Q93615; -.
DR   Reactome; R-CEL-611105; Respiratory electron transport.
DR   PRO; PR:Q93615; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00009187; Expressed in adult organism and 4 other tissues.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; HDA:WormBase.
DR   GO; GO:0009055; F:electron transfer activity; IBA:GO_Central.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR   GO; GO:0033539; P:fatty acid beta-oxidation using acyl-CoA dehydrogenase; IBA:GO_Central.
DR   CDD; cd01715; ETF_alpha; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR014730; ETF_a/b_N.
DR   InterPro; IPR001308; ETF_a/FixB.
DR   InterPro; IPR033947; ETF_alpha_N.
DR   InterPro; IPR014731; ETF_asu_C.
DR   InterPro; IPR018206; ETF_asu_C_CS.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR43153; PTHR43153; 1.
DR   Pfam; PF01012; ETF; 1.
DR   Pfam; PF00766; ETF_alpha; 1.
DR   PIRSF; PIRSF000089; Electra_flavoP_a; 1.
DR   SMART; SM00893; ETF; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   PROSITE; PS00696; ETF_ALPHA; 1.
PE   3: Inferred from homology;
KW   Electron transport; FAD; Flavoprotein; Mitochondrion; Reference proteome;
KW   Transit peptide; Transport.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..332
FT                   /note="Probable electron transfer flavoprotein subunit
FT                   alpha, mitochondrial"
FT                   /id="PRO_0000008655"
FT   BINDING         275..303
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   332 AA;  34455 MW;  556BEABE6F5C450E CRC64;
     MLSARTVLSR AGLISNASRL NSTLVVAEHD ETKLAPITLN AITAASKLGN EVSVLVTGAN
     ATKVAEQVAK VNGVKRVLVA QDEKLKNNLP ERVAPVILAS QKQFNFTAIT AGSSAFGRGV
     IPRVAAKLDV SSISDVTEVH SADSFTRTLY AGNAVKKVKS TAPIKLLTFR GTSFEPAKEG
     GSGAVENAPS ADIKTDLSEF LGQELSKSER PDLATAKVVV SGGRGLKSGD NFKLIYDLAD
     KLGAGVGASR AAVDAGYVPN DMQVGQTGKI VAPELYIAIG ISGAIQHLAG MKDSKVIVAI
     NKDPDAPIFQ VADIGLKADL FKAVPELTAA LP