ID   ETFA_CRYGW              Reviewed;         346 AA.
AC   Q5Y223; E6RBT6;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Probable electron transfer flavoprotein subunit alpha, mitochondrial;
DE            Short=Alpha-ETF;
DE   Flags: Precursor;
GN   Name=ETF1; OrderedLocusNames=CGB_I1080C;
OS   Cryptococcus gattii serotype B (strain WM276 / ATCC MYA-4071)
OS   (Filobasidiella gattii) (Cryptococcus bacillisporus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus gattii species complex.
OX   NCBI_TaxID=367775;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=WM276 / ATCC MYA-4071;
RX   PubMed=15538538; DOI=10.1371/journal.pbio.0020384;
RA   Fraser J.A., Diezmann S., Subaran R.L., Allen A., Lengeler K.B.,
RA   Dietrich F.S., Heitman J.;
RT   "Convergent evolution of chromosomal sex-determining regions in the animal
RT   and fungal kingdoms.";
RL   PLoS Biol. 2:2243-2255(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WM276 / ATCC MYA-4071;
RX   PubMed=21304167; DOI=10.1128/mbio.00342-10;
RA   D'Souza C.A., Kronstad J.W., Taylor G., Warren R., Yuen M., Hu G.,
RA   Jung W.H., Sham A., Kidd S.E., Tangen K., Lee N., Zeilmaker T., Sawkins J.,
RA   McVicker G., Shah S., Gnerre S., Griggs A., Zeng Q., Bartlett K., Li W.,
RA   Wang X., Heitman J., Stajich J.E., Fraser J.A., Meyer W., Carter D.,
RA   Schein J., Krzywinski M., Kwon-Chung K.J., Varma A., Wang J., Brunham R.,
RA   Fyfe M., Ouellette B.F.F., Siddiqui A., Marra M., Jones S., Holt R.,
RA   Birren B.W., Galagan J.E., Cuomo C.A.;
RT   "Genome variation in Cryptococcus gattii, an emerging pathogen of
RT   immunocompetent hosts.";
RL   MBio 2:E342-E342(2011).
CC   -!- FUNCTION: The electron transfer flavoprotein serves as a specific
CC       electron acceptor for several dehydrogenases, including five acyl-CoA
CC       dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers
CC       the electrons to the main mitochondrial respiratory chain via ETF-
CC       ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity).
CC       {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC       Note=Binds 1 FAD per dimer. {ECO:0000250};
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ETF alpha-subunit/FixB family.
CC       {ECO:0000305}.
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DR   EMBL; AY710430; AAV28773.1; -; Genomic_DNA.
DR   EMBL; CP000294; ADV24319.1; -; Genomic_DNA.
DR   RefSeq; XP_003196106.1; XM_003196058.1.
DR   AlphaFoldDB; Q5Y223; -.
DR   SMR; Q5Y223; -.
DR   EnsemblFungi; ADV24319; ADV24319; CGB_I1080C.
DR   GeneID; 10186258; -.
DR   KEGG; cgi:CGB_I1080C; -.
DR   VEuPathDB; FungiDB:CGB_I1080C; -.
DR   eggNOG; KOG3954; Eukaryota.
DR   HOGENOM; CLU_034178_0_1_1; -.
DR   Proteomes; UP000007805; Chromosome I.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   CDD; cd01715; ETF_alpha; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR014730; ETF_a/b_N.
DR   InterPro; IPR001308; ETF_a/FixB.
DR   InterPro; IPR033947; ETF_alpha_N.
DR   InterPro; IPR014731; ETF_asu_C.
DR   InterPro; IPR018206; ETF_asu_C_CS.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR43153; PTHR43153; 1.
DR   Pfam; PF01012; ETF; 1.
DR   Pfam; PF00766; ETF_alpha; 1.
DR   PIRSF; PIRSF000089; Electra_flavoP_a; 1.
DR   SMART; SM00893; ETF; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   PROSITE; PS00696; ETF_ALPHA; 1.
PE   3: Inferred from homology;
KW   Electron transport; FAD; Flavoprotein; Mitochondrion; Transit peptide;
KW   Transport.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..346
FT                   /note="Probable electron transfer flavoprotein subunit
FT                   alpha, mitochondrial"
FT                   /id="PRO_0000008656"
FT   BINDING         285..313
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   346 AA;  36060 MW;  625AD165917ED6B6 CRC64;
     MLYRSALRTS RAFTPRLALS HSRLVSSLVF LEHKAGKLSE ASLSAVTAAK TLGNDTHGLL
     VGTKSEIENA LDRAKEIKGL SKIYLARSDS YSHSLAEALA SLLASIVSAK DVSHLFAAHT
     AVGKNVFPRL AGLLDSSLIA DIIALESSGD TFTRPIYAGN AVLTIKSSPK DSVKIVTVRS
     TAFDKAPVAA GSAVIEDVDI ITVDTPTQFV SEELTVSSRP DLASAARVVS GGRALKSKES
     FDAILNPLAD SLGAAVGASR AAVDAGYADN SLQVGQTGKV VAPELYVAIG ISGAIQHLAG
     MKESKMIIAI NKDPDAPIFQ VADVGLVADL FESVPQLVKE LGNVKV