ID   ETFA_MEGEL              Reviewed;         338 AA.
AC   O85692;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Electron transfer flavoprotein subunit alpha;
DE            Short=Alpha-ETF;
DE   AltName: Full=Electron transfer flavoprotein large subunit;
DE            Short=ETFLS;
GN   Name=etfA;
OS   Megasphaera elsdenii.
OC   Bacteria; Firmicutes; Negativicutes; Veillonellales; Veillonellaceae;
OC   Megasphaera.
OX   NCBI_TaxID=907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 25940 / DSM 20460 / JCM 1772 / NCIB 8927;
RX   PubMed=9694853; DOI=10.1074/jbc.273.33.21015;
RA   O'Neill H., Mayhew S.G., Butler G.;
RT   "Cloning and analysis of the genes for a novel electron-transferring
RT   flavoprotein from Megasphaera elsdenii. Expression and characterization of
RT   the recombinant protein.";
RL   J. Biol. Chem. 273:21015-21024(1998).
CC   -!- FUNCTION: The electron transfer flavoprotein serves as a specific
CC       electron acceptor for other dehydrogenases. It transfers the electrons
CC       to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF
CC       dehydrogenase) (By similarity). {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC       Note=Binds 2 FAD per dimer.;
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit.
CC   -!- SIMILARITY: Belongs to the ETF alpha-subunit/FixB family.
CC       {ECO:0000305}.
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DR   EMBL; AF072475; AAC31170.1; -; Genomic_DNA.
DR   AlphaFoldDB; O85692; -.
DR   SMR; O85692; -.
DR   BioCyc; MetaCyc:MON-21345; -.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   CDD; cd01715; ETF_alpha; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR014730; ETF_a/b_N.
DR   InterPro; IPR001308; ETF_a/FixB.
DR   InterPro; IPR033947; ETF_alpha_N.
DR   InterPro; IPR014731; ETF_asu_C.
DR   InterPro; IPR018206; ETF_asu_C_CS.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR43153; PTHR43153; 1.
DR   Pfam; PF01012; ETF; 1.
DR   Pfam; PF00766; ETF_alpha; 1.
DR   PIRSF; PIRSF000089; Electra_flavoP_a; 1.
DR   SMART; SM00893; ETF; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   PROSITE; PS00696; ETF_ALPHA; 1.
PE   3: Inferred from homology;
KW   Electron transport; FAD; Flavoprotein; Transport.
FT   CHAIN           1..338
FT                   /note="Electron transfer flavoprotein subunit alpha"
FT                   /id="PRO_0000167850"
FT   BINDING         275..303
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   338 AA;  36125 MW;  63FBD4CCF111AE77 CRC64;
     MDLAEYKGIY VIAEQFEGKL RDVSFELLGQ ARILADTIGD EVGAILIGKD VKPLAQELIA
     HGAHKVYVYD DPQLEHYNTT AYAKVICDFF HEEKPNVFLV GATNIGRDLG PRVANSLKTG
     LTADCTQLGV DDDKKTIVWT RPALGGNIMA EIICPDNRPQ MGTVRPHVFK KPEADPSATG
     EVIEKKANLS DADFMTKFVE LIKLGGEGVK IEDADVIVAG GRGMNSEEPF KTGILKECAD
     VLGGAVGASR AAVDAGWIDA LHQVGQTGKT VGPKIYIACA ISGAIQPLAG MTGSDCIIAI
     NKDEDAPIFK VCDYGIVGDV FKVLPLLTEA IKKQKGIA