ID   ETFA_MYCLE              Reviewed;         318 AA.
AC   O33096;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Electron transfer flavoprotein subunit alpha;
DE            Short=Alpha-ETF;
DE   AltName: Full=Electron transfer flavoprotein large subunit;
DE            Short=ETFLS;
GN   Name=etfA; Synonyms=fixB; OrderedLocusNames=ML1711; ORFNames=MLCB637.04;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: The electron transfer flavoprotein serves as a specific
CC       electron acceptor for other dehydrogenases. It transfers the electrons
CC       to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF
CC       dehydrogenase) (By similarity). {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC       Note=Binds 1 FAD per dimer. {ECO:0000250};
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit.
CC   -!- SIMILARITY: Belongs to the ETF alpha-subunit/FixB family.
CC       {ECO:0000305}.
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DR   EMBL; Z99263; CAB16419.1; -; Genomic_DNA.
DR   EMBL; AL583923; CAC30664.1; -; Genomic_DNA.
DR   PIR; T45397; T45397.
DR   RefSeq; NP_302178.1; NC_002677.1.
DR   RefSeq; WP_010908499.1; NC_002677.1.
DR   AlphaFoldDB; O33096; -.
DR   SMR; O33096; -.
DR   STRING; 272631.ML1711; -.
DR   EnsemblBacteria; CAC30664; CAC30664; CAC30664.
DR   KEGG; mle:ML1711; -.
DR   PATRIC; fig|272631.5.peg.3224; -.
DR   Leproma; ML1711; -.
DR   eggNOG; COG2025; Bacteria.
DR   HOGENOM; CLU_034178_0_1_11; -.
DR   OMA; WRPYAEQ; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   CDD; cd01715; ETF_alpha; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR014730; ETF_a/b_N.
DR   InterPro; IPR001308; ETF_a/FixB.
DR   InterPro; IPR033947; ETF_alpha_N.
DR   InterPro; IPR014731; ETF_asu_C.
DR   InterPro; IPR018206; ETF_asu_C_CS.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR43153; PTHR43153; 1.
DR   Pfam; PF01012; ETF; 1.
DR   Pfam; PF00766; ETF_alpha; 1.
DR   PIRSF; PIRSF000089; Electra_flavoP_a; 1.
DR   SMART; SM00893; ETF; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   PROSITE; PS00696; ETF_ALPHA; 1.
PE   3: Inferred from homology;
KW   Electron transport; FAD; Flavoprotein; Reference proteome; Transport.
FT   CHAIN           1..318
FT                   /note="Electron transfer flavoprotein subunit alpha"
FT                   /id="PRO_0000167852"
FT   BINDING         257..285
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   318 AA;  31837 MW;  2E90F9F7A5CCFC6E CRC64;
     MAEALVLVEH TEGALKKVSA ELITAARVLG EPAAVVVGTP GTSAPLVDGL KTAGAAKIYV
     AESDAADKYL ITPVVDVLAA LAESSAPAAV LLAATADGKE IGGRLAARIG SGLLVDVVDV
     REGAVGVHSV FGGVFIVEAQ ANGDTPVITV RAGAVEAQPA EGAGEQVSVE VPAPAENATK
     ITARAPAVVD NRPDLTEATV VVSGGRGVGS ADNFSVVEAL ADSLGAAVGA SRAAVDSGYY
     PGQFQIGQTG KTVSPQLYIA LGISGAIQHR AGMQTSKTIV AVNKDEEAPI FEIADFGVVG
     DLFKVAPQLT DGIKARKG