ID   ETFA_PSEAE              Reviewed;         309 AA.
AC   Q9HZP7;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Electron transfer flavoprotein subunit alpha;
DE            Short=Alpha-ETF;
DE   AltName: Full=Electron transfer flavoprotein large subunit;
DE            Short=ETFLS;
GN   Name=etfA; OrderedLocusNames=PA2951;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: The electron transfer flavoprotein serves as a specific
CC       electron acceptor for other dehydrogenases. It transfers the electrons
CC       to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF
CC       dehydrogenase) (By similarity). {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC       Note=Binds 1 FAD per dimer. {ECO:0000250};
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ETF alpha-subunit/FixB family.
CC       {ECO:0000305}.
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DR   EMBL; AE004091; AAG06339.1; -; Genomic_DNA.
DR   PIR; B83277; B83277.
DR   RefSeq; NP_251641.1; NC_002516.2.
DR   RefSeq; WP_003091099.1; NZ_QZGE01000009.1.
DR   AlphaFoldDB; Q9HZP7; -.
DR   SMR; Q9HZP7; -.
DR   STRING; 287.DR97_4988; -.
DR   PaxDb; Q9HZP7; -.
DR   PRIDE; Q9HZP7; -.
DR   DNASU; 882932; -.
DR   EnsemblBacteria; AAG06339; AAG06339; PA2951.
DR   GeneID; 882932; -.
DR   KEGG; pae:PA2951; -.
DR   PATRIC; fig|208964.12.peg.3097; -.
DR   PseudoCAP; PA2951; -.
DR   HOGENOM; CLU_034178_0_0_6; -.
DR   InParanoid; Q9HZP7; -.
DR   OMA; WRPYAEQ; -.
DR   PhylomeDB; Q9HZP7; -.
DR   BioCyc; PAER208964:G1FZ6-3002-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0009055; F:electron transfer activity; IBA:GO_Central.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR   GO; GO:0033539; P:fatty acid beta-oxidation using acyl-CoA dehydrogenase; IBA:GO_Central.
DR   CDD; cd01715; ETF_alpha; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR014730; ETF_a/b_N.
DR   InterPro; IPR001308; ETF_a/FixB.
DR   InterPro; IPR033947; ETF_alpha_N.
DR   InterPro; IPR014731; ETF_asu_C.
DR   InterPro; IPR018206; ETF_asu_C_CS.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR43153; PTHR43153; 1.
DR   Pfam; PF01012; ETF; 1.
DR   Pfam; PF00766; ETF_alpha; 1.
DR   PIRSF; PIRSF000089; Electra_flavoP_a; 1.
DR   SMART; SM00893; ETF; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   PROSITE; PS00696; ETF_ALPHA; 1.
PE   3: Inferred from homology;
KW   Electron transport; FAD; Flavoprotein; Reference proteome; Transport.
FT   CHAIN           1..309
FT                   /note="Electron transfer flavoprotein subunit alpha"
FT                   /id="PRO_0000287791"
FT   BINDING         253..281
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   309 AA;  31423 MW;  699634E5F3F8A468 CRC64;
     MAILVIAEHN NAALAAATLN TVAAAKAIGG DIHVLVAGQN VAAVAEAAAK VEGVSKVLVA
     DNAAYAHQLP ENVAPLIAEL GKNYSHVLAP ATTNGKNFLP RVAALLDVDQ ISEIVEVVSP
     DTFKRPIYAG NAIATVQSSA AVKVITVRTT GFDAVAAEGG SAAVEQVSGP ADAGKSAFVG
     EELAKSDRPE LTAAKIVVSG GRGMQNGDNF KILYALADKL GAAVGASRAA VDAGFVPNDM
     QVGQTGKIVA PQLYIAVGIS GAIQHLAGMK DSKVIVAINK DEEAPIFQVA DYGLVADLFD
     AVPELEKAV