ID   ETFA_THETC              Reviewed;         330 AA.
AC   P71153; D9TPZ8; O08252;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Electron transfer flavoprotein subunit alpha;
DE            Short=Alpha-ETF;
DE   AltName: Full=Electron transfer flavoprotein large subunit;
DE            Short=ETFLS;
GN   Name=etfA; OrderedLocusNames=Tthe_1658;
OS   Thermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM 571 /
OS   NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM 00135 / 2032) (Clostridium
OS   thermosaccharolyticum).
OC   Bacteria; Firmicutes; Clostridia; Thermoanaerobacterales;
OC   Thermoanaerobacterales Family III. Incertae Sedis; Thermoanaerobacterium.
OX   NCBI_TaxID=580327;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 7956 / DSM 571 / NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM
RC   00135 / 2032;
RA   van Rinsum A., Bronnenmeier K., Staudenbauer W.L.;
RL   Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 7956 / DSM 571 / NCIMB 9385 / NCA 3814 / NCTC 13789 / WDCM
RC   00135 / 2032;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L.,
RA   Pitluck S., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L.,
RA   Chang Y.-J., Jeffries C., Kyrpides N., Ivanova N., Mikhailova N.,
RA   Hemme C.L., Woyke T.;
RT   "Complete sequence of Thermoanaerobacterium thermosaccharolyticum DSM
RT   571.";
RL   Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The electron transfer flavoprotein serves as a specific
CC       electron acceptor for other dehydrogenases. It transfers the electrons
CC       to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF
CC       dehydrogenase) (By similarity). {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC       Note=Binds 1 FAD per dimer. {ECO:0000250};
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit.
CC   -!- SIMILARITY: Belongs to the ETF alpha-subunit/FixB family.
CC       {ECO:0000305}.
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DR   EMBL; Z82038; CAB04791.1; -; Genomic_DNA.
DR   EMBL; Z92974; CAB07498.1; -; Genomic_DNA.
DR   EMBL; CP002171; ADL69167.1; -; Genomic_DNA.
DR   PIR; T45288; T45288.
DR   RefSeq; WP_013298134.1; NC_014410.1.
DR   AlphaFoldDB; P71153; -.
DR   SMR; P71153; -.
DR   STRING; 580327.Tthe_1658; -.
DR   EnsemblBacteria; ADL69167; ADL69167; Tthe_1658.
DR   KEGG; ttm:Tthe_1658; -.
DR   eggNOG; COG2025; Bacteria.
DR   HOGENOM; CLU_034178_1_1_9; -.
DR   OMA; RYVFGNK; -.
DR   OrthoDB; 1400253at2; -.
DR   Proteomes; UP000001626; Chromosome.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   CDD; cd01715; ETF_alpha; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR014730; ETF_a/b_N.
DR   InterPro; IPR001308; ETF_a/FixB.
DR   InterPro; IPR033947; ETF_alpha_N.
DR   InterPro; IPR014731; ETF_asu_C.
DR   InterPro; IPR018206; ETF_asu_C_CS.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR43153; PTHR43153; 1.
DR   Pfam; PF01012; ETF; 1.
DR   Pfam; PF00766; ETF_alpha; 1.
DR   PIRSF; PIRSF000089; Electra_flavoP_a; 1.
DR   SMART; SM00893; ETF; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   PROSITE; PS00696; ETF_ALPHA; 1.
PE   3: Inferred from homology;
KW   Electron transport; FAD; Flavoprotein; Reference proteome; Transport.
FT   CHAIN           1..330
FT                   /note="Electron transfer flavoprotein subunit alpha"
FT                   /id="PRO_0000167849"
FT   BINDING         270..298
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        166..176
FT                   /note="MKRAIRDDTRD -> IKELLEMIQEM (in Ref. 1; CAB04791/
FT                   CAB07498)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        237
FT                   /note="L -> R (in Ref. 1; CAB04791/CAB07498)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   330 AA;  35555 MW;  DDE0F20FDA14B681 CRC64;
     MNDYKDIWIF AEQRNGKLMN VAIEILGEAR KLADKKGVNV GAVLIGHNVE NLSKDLISFG
     ADIVYVVDNP LLSNYTTEGY AKAISELAKE YKPEVILYGA TFIGRDLAPR IASRLMTGLT
     ADCTGLDIDE NGLLLQTRPA FGGNLMATIK CPDKRPQMST VRPGVMKRAI RDDTRDGKVI
     KFDADINESD IRTKILSIAK EAKNVVNLEE ADIIVSGGRG IGGPDGFNII KELADVLGGV
     VGASRATVDA GWITSDHQVG QTGKTVRPKL YIACGISGAI QHLAGMSNSG TIVAINKNPD
     APIFKFADYG IVGDLFKVIP VLIEEIKKLK