ETFR1_MOUSE
ID ETFR1_MOUSE Reviewed; 86 AA.
AC Q91V16; B2KFC1; Q675B1; Q8VDL7;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Electron transfer flavoprotein regulatory factor 1 {ECO:0000250|UniProtKB:Q6IPR1};
DE AltName: Full=Growth hormone-inducible soluble protein {ECO:0000303|Ref.1};
DE AltName: Full=LYR motif-containing protein 5 {ECO:0000250|UniProtKB:Q6IPR1};
GN Name=Etfrf1 {ECO:0000250|UniProtKB:Q6IPR1};
GN Synonyms=Lyrm5 {ECO:0000312|MGI:MGI:1914886};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Li Y., Coschigano K.T., Kopchick J.K.;
RT "Polymerase chain reaction-based subtractive hybridization: identification
RT of a novel interscapular brown adipose tissue gene from growth hormone
RT antagonist mice.";
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT GLY-28.
RC STRAIN=A/J; TISSUE=Lung;
RA Manenti G., Galbiati F., Pettinicchio A., Dragani T.A.;
RT "Complex in vitro allelic effects of mouse Pas1 candidate genes in human
RT lung cancer cell lines.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-28.
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-85, AND VARIANT GLY-28.
RC STRAIN=A/J;
RX PubMed=15064703; DOI=10.1038/sj.onc.1207584;
RA Manenti G., Galbiati F., Gianni-Barrera R., Pettinicchio A., Acevedo A.,
RA Dragani T.A.;
RT "Haplotype sharing suggests that a genomic segment containing six genes
RT accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity
RT in mice.";
RL Oncogene 23:4495-4504(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Acts as a regulator of the electron transfer flavoprotein by
CC promoting the removal of flavin from the ETF holoenzyme (composed of
CC ETFA and ETFB). {ECO:0000250|UniProtKB:Q6IPR1}.
CC -!- SUBUNIT: homotetramer. Interacts with NDUFAB1. Interacts with ETFA.
CC Interacts with ETFB. {ECO:0000250|UniProtKB:Q6IPR1}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q6IPR1}.
CC -!- SIMILARITY: Belongs to the complex I LYR family. {ECO:0000305}.
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DR EMBL; AF412298; AAL07804.1; -; mRNA.
DR EMBL; AF412299; AAL07805.1; -; mRNA.
DR EMBL; AF412300; AAL07806.1; -; mRNA.
DR EMBL; AY753325; AAV31717.1; -; mRNA.
DR EMBL; AK015530; BAC25464.1; -; mRNA.
DR EMBL; CU207316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC021522; AAH21522.1; -; mRNA.
DR EMBL; AY490388; AAT72334.1; -; Genomic_DNA.
DR CCDS; CCDS39706.1; -.
DR RefSeq; NP_001157100.1; NM_001163628.1.
DR RefSeq; NP_598449.1; NM_133688.3.
DR RefSeq; XP_006507045.1; XM_006506982.2.
DR RefSeq; XP_006507046.1; XM_006506983.3.
DR RefSeq; XP_006507047.1; XM_006506984.2.
DR RefSeq; XP_017177210.1; XM_017321721.1.
DR AlphaFoldDB; Q91V16; -.
DR SMR; Q91V16; -.
DR BioGRID; 212324; 2.
DR STRING; 10090.ENSMUSP00000107354; -.
DR PhosphoSitePlus; Q91V16; -.
DR MaxQB; Q91V16; -.
DR PaxDb; Q91V16; -.
DR PeptideAtlas; Q91V16; -.
DR PRIDE; Q91V16; -.
DR ProteomicsDB; 275485; -.
DR Antibodypedia; 48706; 44 antibodies from 11 providers.
DR Ensembl; ENSMUST00000039729; ENSMUSP00000039433; ENSMUSG00000040370.
DR Ensembl; ENSMUST00000111719; ENSMUSP00000107348; ENSMUSG00000040370.
DR Ensembl; ENSMUST00000111721; ENSMUSP00000107350; ENSMUSG00000040370.
DR Ensembl; ENSMUST00000111723; ENSMUSP00000107352; ENSMUSG00000040370.
DR Ensembl; ENSMUST00000111724; ENSMUSP00000107353; ENSMUSG00000040370.
DR Ensembl; ENSMUST00000111725; ENSMUSP00000107354; ENSMUSG00000040370.
DR Ensembl; ENSMUST00000111726; ENSMUSP00000107355; ENSMUSG00000040370.
DR GeneID; 67636; -.
DR KEGG; mmu:67636; -.
DR UCSC; uc009erf.2; mouse.
DR CTD; 144363; -.
DR MGI; MGI:1914886; Etfrf1.
DR VEuPathDB; HostDB:ENSMUSG00000040370; -.
DR eggNOG; ENOG502S4S4; Eukaryota.
DR GeneTree; ENSGT00390000001810; -.
DR HOGENOM; CLU_141157_2_0_1; -.
DR InParanoid; Q91V16; -.
DR OMA; PQGYDYF; -.
DR OrthoDB; 1606295at2759; -.
DR PhylomeDB; Q91V16; -.
DR TreeFam; TF300251; -.
DR BioGRID-ORCS; 67636; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Lyrm5; mouse.
DR PRO; PR:Q91V16; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q91V16; protein.
DR Bgee; ENSMUSG00000040370; Expressed in interventricular septum and 242 other tissues.
DR Genevisible; Q91V16; MM.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0022904; P:respiratory electron transport chain; ISS:UniProtKB.
DR CDD; cd20265; Complex1_LYR_ETFRF1_LYRM5; 1.
DR InterPro; IPR008011; Complex1_LYR_dom.
DR InterPro; IPR045296; Complex1_LYR_ETFRF1_LYRM5.
DR Pfam; PF05347; Complex1_LYR; 1.
PE 1: Evidence at protein level;
KW Mitochondrion; Reference proteome.
FT CHAIN 1..86
FT /note="Electron transfer flavoprotein regulatory factor 1"
FT /id="PRO_0000251183"
FT VARIANT 28
FT /note="D -> G"
FT /evidence="ECO:0000269|PubMed:15064703,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
SQ SEQUENCE 86 AA; 10391 MW; D9643C6FC573C3BC CRC64;
MANSLRGEVL TLYKNLLYLG RDYPKGADYF KRRLKNVFLK NKDVEDPEKI KELIARGEFV
MKELEALYFL RKYRAMKQRY YSDTKV
