ID   ETFS_ASFK5              Reviewed;        1134 AA.
AC   P0C9A7;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 31.
DE   RecName: Full=Early transcription factor large subunit homolog {ECO:0000250|UniProtKB:Q89525};
DE            EC=3.6.4.13;
DE   AltName: Full=ATP-dependent helicase VETFS homolog {ECO:0000250|UniProtKB:Q89525};
GN   OrderedLocusNames=Ken-118;
OS   African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Asfuvirales; Asfarviridae; Asfivirus.
OX   NCBI_TaxID=561445;
OH   NCBI_TaxID=6937; Ornithodoros (relapsing fever ticks).
OH   NCBI_TaxID=85517; Phacochoerus aethiopicus (Warthog).
OH   NCBI_TaxID=41426; Phacochoerus africanus (Warthog).
OH   NCBI_TaxID=273792; Potamochoerus larvatus (Bushpig).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Kutish G.F., Rock D.L.;
RT   "African swine fever virus genomes.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative initation factor. {ECO:0000250|UniProtKB:P04308}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000250|UniProtKB:P04308};
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:Q89525}. Note=Found
CC       in association with viral nucleoid. {ECO:0000250|UniProtKB:Q89525}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC       {ECO:0000250|UniProtKB:Q89525}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY261360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Proteomes; UP000000861; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Helicase; Hydrolase; Late protein; Nucleotide-binding;
KW   Transcription; Transcription regulation; Virion.
FT   CHAIN           1..1134
FT                   /note="Early transcription factor large subunit homolog"
FT                   /id="PRO_0000373111"
FT   DOMAIN          52..352
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          524..725
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   MOTIF           281..284
FT                   /note="DEAH box"
FT   BINDING         99..106
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   1134 AA;  129396 MW;  983708362E882AAE CRC64;
     MAYPELDAAD FLQQLARRKE FKSLISPPVD QKKLIHDLRS HFVQIGGPGC EKGGRAFFPC
     DPYASPFPSI KGLQLHNAQL FVQNFQNPNT PYSRLLLNWQ TGTGKSIAAI AIARQFMNHY
     MNFIENAPWI FVVGFTRAII QTEMLRRPEL GFVSYKEVAE LHRLLHIAKQ SGSTTSVESR
     HLNGFVSTLK RRLTDRNRGG FFQFYGYKEF ASKLFNITSK GEEKNFDVLS LFHRSDEAED
     TLNENDISQF VQKISEAESN GLIRVNQKIM EQLRGGLLIA DEIHNVYNIQ ERNNYGIALQ
     YVLDAFPPHQ APRAVFMSAT PVTGSVMEYV DLLNLLVPRH ELPNGQPLQR QQLFDNSGHS
     VKWKKDALAL VERLSTGRVS FLLDTNTNYY PERIFAGKML SYRNEMLPYL HFIECPMSDY
     QLETLKQLGP DPKISSNAYS IYDMVFPNPK FSKQTEPKAY GLFNSTETPA ALSMASTDWL
     LENGVQIIEP SRRTPFNVSG SFLSLQPPTH ISGLAFYSGK YTQMMKDILS IIRQGRGKIL
     IYHNRVRMSG VLILQEILQS NGILNEVSSP VGTTRCSICA AIRDDHTTHS DHQFIPARFT
     ILHSEIEPAV RERSLALFNA SSNLEGHQLR ILIGSKVIVE GLNFQAVRYE MIMSLPLDIP
     RLIQVFGRVV RKNSHMELPP NERNVTIYLY VSTTPDGGPE LAKYAQKLKE YILIQEGDKA
     LRKHAIDGFT NQIKIDKPML ESLPLSPSIT PANVGATVLN TFEAYGYGEQ EVKTISNIII
     SLFMARPVWT YSELWKAVST PKLIQGITID NKLFSEDNFA LALVSLCYSK NQCKELCIQN
     RLCTIMHVPA KPEHLYIAAV LNYKKEPVLD IETYIRDFQP PTMHSIRITK YLEHSQTKEP
     FQVLYEKFQK DFQDEPMEQV LIHYPASFHY TMLEALIIDN LAGMGALVEV YKKFFIAFSK
     KDIQPFPDIF KIISHVPGDD DTLVGYATED SVRLITSRQD KTWHEIPLYM LNINVKRKEN
     DIVIGYMESK GKTLKFKIRP PIQVLKKNEI TDIRMLNRGA VCETRGREEQ QKIADQLGIS
     LNLTKISAIK LCLLIRNTLL QKEMEARNQP NGMQDGIRWF YLFNDKMPSL VHTS