位置:首页 > 蛋白库 > ETHD_METRA
ETHD_METRA
ID   ETHD_METRA              Reviewed;         142 AA.
AC   E9F647;
DT   05-DEC-2018, integrated into UniProtKB/Swiss-Prot.
DT   04-MAR-2015, sequence version 2.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Conidial pigment biosynthesis dehydratase EthD {ECO:0000303|PubMed:28447400};
DE            EC=1.-.-.- {ECO:0000305|PubMed:25445307};
GN   Name=EthD {ECO:0000303|PubMed:28447400}; ORFNames=MAA_07746;
OS   Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium
OS   anisopliae (strain ARSEF 23)).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Metarhizium.
OX   NCBI_TaxID=655844;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ARSEF 23 / ATCC MYA-3075;
RX   PubMed=21253567; DOI=10.1371/journal.pgen.1001264;
RA   Gao Q., Jin K., Ying S.-H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X.,
RA   Xie X.-Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S.,
RA   Zhong Y., Ma L.-J., St Leger R.J., Zhao G.-P., Pei Y., Feng M.-G., Xia Y.,
RA   Wang C.;
RT   "Genome sequencing and comparative transcriptomics of the model
RT   entomopathogenic fungi Metarhizium anisopliae and M. acridum.";
RL   PLoS Genet. 7:E1001264-E1001264(2011).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ARSEF 23 / ATCC MYA-3075;
RX   PubMed=25368161; DOI=10.1073/pnas.1412662111;
RA   Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S.,
RA   St Leger R.J., Wang C.;
RT   "Trajectory and genomic determinants of fungal-pathogen speciation and host
RT   adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014).
RN   [3]
RP   FUNCTION.
RX   PubMed=20382249; DOI=10.1016/j.fgb.2010.03.011;
RA   Fang W., Fernandes E.K., Roberts D.W., Bidochka M.J., St Leger R.J.;
RT   "A laccase exclusively expressed by Metarhizium anisopliae during isotropic
RT   growth is involved in pigmentation, tolerance to abiotic stresses and
RT   virulence.";
RL   Fungal Genet. Biol. 47:602-607(2010).
RN   [4]
RP   FUNCTION.
RX   PubMed=25445307; DOI=10.1016/j.fgb.2014.10.018;
RA   Chen Y., Feng P., Shang Y., Xu Y.J., Wang C.;
RT   "Biosynthesis of non-melanin pigment by a divergent polyketide synthase in
RT   Metarhizium robertsii.";
RL   Fungal Genet. Biol. 81:142-149(2015).
RN   [5]
RP   IDENTIFICATION, FUNCTION, DISRUPTION PHENOTYPE, AND PATHWAY.
RX   PubMed=28447400; DOI=10.1111/1462-2920.13777;
RA   Zeng G., Chen X., Zhang X., Zhang Q., Xu C., Mi W., Guo N., Zhao H.,
RA   You Y., Dryburgh F.J., Bidochka M.J., St Leger R.J., Zhang L., Fang W.;
RT   "Genome-wide identification of pathogenicity, conidiation and colony
RT   sectorization genes in Metarhizium robertsii.";
RL   Environ. Microbiol. 19:3896-3908(2017).
RN   [6]
RP   IDENTIFICATION, AND FUNCTION.
RX   PubMed=29958281; DOI=10.1371/journal.pgen.1007472;
RA   Zeng G., Zhang P., Zhang Q., Zhao H., Li Z., Zhang X., Wang C., Yin W.B.,
RA   Fang W.;
RT   "Duplication of a Pks gene cluster and subsequent functional
RT   diversification facilitate environmental adaptation in Metarhizium
RT   species.";
RL   PLoS Genet. 14:E1007472-E1007472(2018).
CC   -!- FUNCTION: Dehydratase; part of the Pks1 gene cluster that mediates the
CC       biosynthesis of an anthraquinone derivative pigment that contributes to
CC       conidial pigmentation that provides protection from UV radiation, heat
CC       and cold stress (PubMed:28447400). The polyketide synthase Pks1
CC       produces 1-acetyl-2,4,6,8-tetrahydroxy-9,10-anthraquinone though
CC       condensation of acetyl-CoA with malonyl-CoA (Probable). The dehydratase
CC       EthD and the laccase Mlac1 further convert the anthraquinone derivative
CC       into the final conidial pigment (Probable).
CC       {ECO:0000269|PubMed:28447400, ECO:0000305|PubMed:29958281}.
CC   -!- PATHWAY: Pigment biosynthesis. {ECO:0000269|PubMed:28447400}.
CC   -!- INDUCTION: Highly expressed during conidiation (PubMed:28447400). A
CC       conserved conidiation regulatory pathway containing BrlA, AbaA and WetA
CC       regulates expression. During conidiation BlrA up-regulates AbaA, which
CC       in turn controls WetA. Moreover, the Hog1 MAPK regulates fungal
CC       conidiation by controlling the conidiation regulatory pathway, and that
CC       all three pigmentation genes Pks1, EthD and Mlac1 exercise feedback
CC       regulation of conidiation (PubMed:28447400).
CC       {ECO:0000269|PubMed:28447400}.
CC   -!- DISRUPTION PHENOTYPE: Leads to the production of dark red conidia
CC       (PubMed:28447400). Does not affect virulence (PubMed:28447400).
CC       {ECO:0000269|PubMed:28447400}.
CC   -!- SIMILARITY: Belongs to the tpcK family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ADNJ02000010; EFY96685.2; -; Genomic_DNA.
DR   RefSeq; XP_007823935.2; XM_007825744.2.
DR   AlphaFoldDB; E9F647; -.
DR   EnsemblFungi; EFY96685; EFY96685; MAA_07746.
DR   GeneID; 19262032; -.
DR   KEGG; maj:MAA_07746; -.
DR   HOGENOM; CLU_115019_0_0_1; -.
DR   Proteomes; UP000002498; Unassembled WGS sequence.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011008; Dimeric_a/b-barrel.
DR   InterPro; IPR009799; EthD_dom.
DR   Pfam; PF07110; EthD; 1.
DR   SUPFAM; SSF54909; SSF54909; 1.
PE   2: Evidence at transcript level;
KW   Monooxygenase; Oxidoreductase.
FT   CHAIN           1..142
FT                   /note="Conidial pigment biosynthesis dehydratase EthD"
FT                   /id="PRO_0000445753"
FT   DOMAIN          25..121
FT                   /note="EthD"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   142 AA;  16524 MW;  1BB0F5A8BB033FA0 CRC64;
     MAISDSVSPE PQQLLCLTIT AFRKPGMSEA AYREYMTKTH APLVSGLMEE YGIVRYNMTH
     NNSKSRPLLF QLYDPEFSKL SDYDCIVQFV FRRMEDFLRM KSDPRFLEKV APDHQKFADT
     SRSTMTIGYF EEFLENGKVV PK
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024