ID   ETIF1_DROME             Reviewed;         110 AA.
AC   Q9VZS3;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Eukaryotic translation initiation factor eIF1 {ECO:0000305};
DE   AltName: Full=Protein translation factor SUI1 homolog;
GN   Name=eIF1 {ECO:0000312|FlyBase:FBgn0035423};
GN   ORFNames=CG17737 {ECO:0000312|FlyBase:FBgn0035423};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-40, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RX   PubMed=17372656; DOI=10.1039/b617545g;
RA   Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A.,
RA   Eng J.K., Aebersold R., Tao W.A.;
RT   "An integrated chemical, mass spectrometric and computational strategy for
RT   (quantitative) phosphoproteomics: application to Drosophila melanogaster
RT   Kc167 cells.";
RL   Mol. Biosyst. 3:275-286(2007).
CC   -!- FUNCTION: Probably involved in translation.
CC   -!- SIMILARITY: Belongs to the SUI1 family. {ECO:0000305}.
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DR   EMBL; AE014296; AAF47744.1; -; Genomic_DNA.
DR   EMBL; AY095068; AAM11396.1; -; mRNA.
DR   RefSeq; NP_647792.1; NM_139535.4.
DR   AlphaFoldDB; Q9VZS3; -.
DR   SMR; Q9VZS3; -.
DR   BioGRID; 63894; 7.
DR   DIP; DIP-22738N; -.
DR   IntAct; Q9VZS3; 4.
DR   STRING; 7227.FBpp0072908; -.
DR   iPTMnet; Q9VZS3; -.
DR   PaxDb; Q9VZS3; -.
DR   PRIDE; Q9VZS3; -.
DR   DNASU; 38398; -.
DR   EnsemblMetazoa; FBtr0073044; FBpp0072908; FBgn0035423.
DR   GeneID; 38398; -.
DR   KEGG; dme:Dmel_CG17737; -.
DR   UCSC; CG17737-RA; d. melanogaster.
DR   CTD; 10209; -.
DR   FlyBase; FBgn0035423; eIF1.
DR   VEuPathDB; VectorBase:FBgn0035423; -.
DR   eggNOG; KOG1770; Eukaryota.
DR   GeneTree; ENSGT00390000015789; -.
DR   HOGENOM; CLU_082805_3_0_1; -.
DR   InParanoid; Q9VZS3; -.
DR   OMA; VENHIHI; -.
DR   OrthoDB; 1493146at2759; -.
DR   PhylomeDB; Q9VZS3; -.
DR   BioGRID-ORCS; 38398; 1 hit in 3 CRISPR screens.
DR   ChiTaRS; CG17737; fly.
DR   GenomeRNAi; 38398; -.
DR   PRO; PR:Q9VZS3; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0035423; Expressed in eye disc (Drosophila) and 28 other tissues.
DR   ExpressionAtlas; Q9VZS3; baseline and differential.
DR   Genevisible; Q9VZS3; DM.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; ISS:FlyBase.
DR   GO; GO:0043614; C:multi-eIF complex; ISS:FlyBase.
DR   GO; GO:0043024; F:ribosomal small subunit binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; ISS:FlyBase.
DR   GO; GO:0071456; P:cellular response to hypoxia; IMP:FlyBase.
DR   GO; GO:0001731; P:formation of translation preinitiation complex; ISS:FlyBase.
DR   CDD; cd11566; eIF1_SUI1; 1.
DR   InterPro; IPR001950; SUI1.
DR   InterPro; IPR036877; SUI1_dom_sf.
DR   InterPro; IPR005874; SUI1_euk.
DR   Pfam; PF01253; SUI1; 1.
DR   PIRSF; PIRSF004499; SUI1_euk; 1.
DR   SUPFAM; SSF55159; SSF55159; 1.
DR   TIGRFAMs; TIGR01160; SUI1_MOF2; 1.
DR   PROSITE; PS50296; SUI1; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Protein biosynthesis; Reference proteome;
KW   Translation regulation.
FT   CHAIN           1..110
FT                   /note="Eukaryotic translation initiation factor eIF1"
FT                   /id="PRO_0000130563"
FT   MOD_RES         40
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000269|PubMed:17372656"
SQ   SEQUENCE   110 AA;  12450 MW;  0E82648472CB6D1B CRC64;
     MSIQNLNTRD PFADAIKGND DDIQDGLVHI RIQQRNGRKT LTTVQGLSAE YDLKKIVRSC
     KKEFACNGTV IEHPEYGEVL QLQGDQRENI CQWLTKVGLA KPDQLKVHGF