ID   AGRP_BOVIN              Reviewed;         134 AA.
AC   P56413;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Agouti-related protein;
DE   Flags: Precursor;
GN   Name=AGRP; Synonyms=AGRT, ART;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Oulmouden A., Petit J.-M., Julien R.;
RL   Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in weight homeostasis. Involved in the control
CC       of feeding behavior through the central melanocortin system. Acts as
CC       alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP
CC       production mediated by stimulation of melanocortin receptors within the
CC       hypothalamus and adrenal gland. Has very low activity with MC5R. Is an
CC       inverse agonist for MC3R and MC4R being able to suppress their
CC       constitutive activity. It promotes MC3R and MC4R endocytosis in an
CC       arrestin-dependent manner. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with melanocortin receptors MC3R, MC4R and MC5R.
CC       {ECO:0000250|UniProtKB:O00253}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O00253}. Golgi
CC       apparatus lumen {ECO:0000250|UniProtKB:O00253}.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC       {ECO:0000250|UniProtKB:O00253}.
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DR   EMBL; AJ002025; CAA05148.1; -; mRNA.
DR   RefSeq; NP_776408.1; NM_173983.1.
DR   AlphaFoldDB; P56413; -.
DR   SMR; P56413; -.
DR   STRING; 9913.ENSBTAP00000019347; -.
DR   PaxDb; P56413; -.
DR   PRIDE; P56413; -.
DR   GeneID; 280987; -.
DR   KEGG; bta:280987; -.
DR   CTD; 181; -.
DR   eggNOG; ENOG502S7K0; Eukaryota.
DR   InParanoid; P56413; -.
DR   OrthoDB; 1404700at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005796; C:Golgi lumen; ISS:UniProtKB.
DR   GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR   GO; GO:0031781; F:type 3 melanocortin receptor binding; ISS:UniProtKB.
DR   GO; GO:0031782; F:type 4 melanocortin receptor binding; ISS:UniProtKB.
DR   GO; GO:0009755; P:hormone-mediated signaling pathway; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; ISS:UniProtKB.
DR   GO; GO:0060259; P:regulation of feeding behavior; ISS:UniProtKB.
DR   Gene3D; 4.10.760.10; -; 1.
DR   InterPro; IPR007733; Agouti.
DR   InterPro; IPR027300; Agouti_dom.
DR   InterPro; IPR036836; Agouti_dom_sf.
DR   PANTHER; PTHR16551; PTHR16551; 1.
DR   Pfam; PF05039; Agouti; 1.
DR   SMART; SM00792; Agouti; 1.
DR   SUPFAM; SSF57055; SSF57055; 1.
DR   PROSITE; PS60024; AGOUTI_1; 1.
DR   PROSITE; PS51150; AGOUTI_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Golgi apparatus; Knottin; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..84
FT                   /evidence="ECO:0000250|UniProtKB:O00253"
FT                   /id="PRO_0000434043"
FT   CHAIN           85..134
FT                   /note="Agouti-related protein"
FT                   /id="PRO_0000001033"
FT   DOMAIN          89..131
FT                   /note="Agouti"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00494"
FT   REGION          113..115
FT                   /note="Interaction with melanocortin receptors"
FT                   /evidence="ECO:0000250"
FT   SITE            84..85
FT                   /note="Cleavage; by PCSK1"
FT                   /evidence="ECO:0000250|UniProtKB:O00253"
FT   DISULFID        89..104
FT                   /evidence="ECO:0000250|UniProtKB:O00253,
FT                   ECO:0000255|PROSITE-ProRule:PRU00494"
FT   DISULFID        96..110
FT                   /evidence="ECO:0000250|UniProtKB:O00253,
FT                   ECO:0000255|PROSITE-ProRule:PRU00494"
FT   DISULFID        103..121
FT                   /evidence="ECO:0000250|UniProtKB:O00253,
FT                   ECO:0000255|PROSITE-ProRule:PRU00494"
FT   DISULFID        107..131
FT                   /evidence="ECO:0000250|UniProtKB:O00253,
FT                   ECO:0000255|PROSITE-ProRule:PRU00494"
FT   DISULFID        112..119
FT                   /evidence="ECO:0000250|UniProtKB:O00253,
FT                   ECO:0000255|PROSITE-ProRule:PRU00494"
SQ   SEQUENCE   134 AA;  14706 MW;  F4B7AE1458B6A24B CRC64;
     MLTAVLLSCA LLLAMPPLQG AQMGPAPLEG IGRPEEALFL ELQGLSLQPS LKRITEEQAE
     ESLLQEAEAK ALAEVLDPEG RKPRSPRRCV RLHESCLGHQ VPCCDPCATC YCRFFNAFCY
     CRKLGTTTNP CSRT