ETR3_ORYSI
ID ETR3_ORYSI Reviewed; 836 AA.
AC Q6T5K2; B8AF44;
DT 16-SEP-2015, integrated into UniProtKB/Swiss-Prot.
DT 16-SEP-2015, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Ethylene receptor 3 {ECO:0000305};
DE Short=OS-ETR3 {ECO:0000303|PubMed:14754915};
DE EC=2.7.13.3 {ECO:0000305};
GN Name=ETR3 {ECO:0000312|EMBL:AAR08915.1};
GN ORFNames=OsI_09484 {ECO:0000312|EMBL:EEC74265.1};
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. IR36;
RX PubMed=14754915; DOI=10.1093/jxb/erh055;
RA Yau C.P., Wang L., Yu M., Zee S.Y., Yip W.K.;
RT "Differential expression of three genes encoding an ethylene receptor in
RT rice during development, and in response to indole-3-acetic acid and silver
RT ions.";
RL J. Exp. Bot. 55:547-556(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
CC -!- FUNCTION: Ethylene receptor related to bacterial two-component
CC regulators. Acts as negative regulator of ethylene signaling. May delay
CC the transition from the vegetative stage to the floral stage by up-
CC regulating GI (GIGANTEA) and RCN1 and cause starch accumulation in
CC stems by down-regulating the alpha-amylase AMY3D.
CC {ECO:0000250|UniProtKB:Q0DWC7}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000305};
CC -!- COFACTOR:
CC Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC Evidence={ECO:0000250|UniProtKB:P49333};
CC Note=Binds 1 copper ion per dimer. {ECO:0000250|UniProtKB:P49333};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:P49333}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the ethylene receptor family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EEC74265.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY434735; AAR08915.1; -; mRNA.
DR EMBL; CM000127; EEC74265.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; Q6T5K2; -.
DR SMR; Q6T5K2; -.
DR STRING; 39946.Q6T5K2; -.
DR Proteomes; UP000007015; Chromosome 2.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0009873; P:ethylene-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:1902531; P:regulation of intracellular signal transduction; IEA:UniProt.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF47384; SSF47384; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Coiled coil; Copper; Endoplasmic reticulum;
KW Ethylene signaling pathway; Kinase; Membrane; Metal-binding;
KW Nucleotide-binding; Receptor; Reference proteome; Transferase;
KW Transmembrane; Transmembrane helix; Two-component regulatory system.
FT CHAIN 1..836
FT /note="Ethylene receptor 3"
FT /id="PRO_0000433868"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 269..413
FT /note="GAF"
FT /evidence="ECO:0000305"
FT DOMAIN 457..691
FT /note="Histidine kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT DOMAIN 718..834
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT COILED 416..452
FT /evidence="ECO:0000255"
FT BINDING 176
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000250|UniProtKB:P49333"
FT BINDING 180
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000250|UniProtKB:P49333"
FT CONFLICT 99..102
FT /note="AARE -> PARQ (in Ref. 1; AAR08915)"
FT CONFLICT 111
FT /note="D -> DG (in Ref. 2; EEC74265)"
FT CONFLICT 130
FT /note="R -> W (in Ref. 1; AAR08915)"
FT CONFLICT 283
FT /note="L -> R (in Ref. 1; AAR08915)"
FT CONFLICT 609
FT /note="R -> W (in Ref. 1; AAR08915)"
FT CONFLICT 671
FT /note="N -> L (in Ref. 1; AAR08915)"
SQ SEQUENCE 836 AA; 92518 MW; 68B7250ECCB8519A CRC64;
MLLSTWTPGC FQGNKILLRS LITWYYLEFM PKLRPFYFLF YLTLPSCATD SPPISDKSSS
IFLPLAQQQQ LVHWMMPPRF RCQDYLLPLL LALSPAAAAA REVEYHHCHC DGGGGGGGGG
LWSMDSIFRR QKVSDLLIAA AYFSIPLEIL YFVAGLRHLL PFRWVLVQFG AFIVLCGLTH
LLTAFTYEPH PFMVVLLLTT AKFLTALVSF LTAITLLTLI PQLLRVKVRE SLLWLKAREL
DREVVLMKRQ EEASWHVRML THEIRKSLDR HTVLYTTLIE LSLVLGLTNC AVWMPAAGEM
CLTHELRRDG GGEDGVVGVD DADVVEVRGS DGVKLLGPDS VLAAASGGKE EGTGAVAAIR
MPMLKVSDFK GGTPEVIQTS YAVLVLVPPA GKSWGRHEME IVEVVAGQVA VALSHATLLE
ESRAMRDRLA EQNRELLQAR RDALMANEAR QAFQGVMSQG MRRPIHSILG LVSMVQEEAL
APEQRLVVDT MARTATVVST LVNDVMEMSA DSRERFPLET RPFHLHAMIR DAACVARCLC
DFRGFGFAVH VENALPDLVV GDERRIFHVL LHMVGNLIGR TEPGHVTLRV RAADDDVLDD
RLGQRWDPRW PSYSTGYSSV KFVIGVKRQQ NGDAGSPLSR RPSGKGIDLR LSFSMCRKLV
QMMQGNIWAI NDPQGLPESM TLVLRFQLQS PLTSSSLGGS FEQKHSSPSC QIAGLKVLLI
DDDDDINLVV ARKLLEKLGC VVSSPPSGSG FLSSVGSSAA AFQLVMVNLE MKRVKALDVA
TRISQYRSGR WPIVMAMASD QKAWEKCAQS GINGILKKPV ILQELKDELA RILQST
