ETR3_ORYSJ
ID ETR3_ORYSJ Reviewed; 836 AA.
AC Q0DWC7; A0A0P0VRB9; Q6K707; Q6K708; Q944U1;
DT 16-SEP-2015, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Ethylene receptor 3 {ECO:0000305};
DE Short=OsETR3 {ECO:0000305};
DE EC=2.7.13.3 {ECO:0000305};
DE AltName: Full=OsPK2 {ECO:0000312|EMBL:AAL29303.2};
GN Name=ETR3;
GN OrderedLocusNames=Os02g0820900 {ECO:0000312|EMBL:BAF10461.1},
GN LOC_Os02g57530 {ECO:0000305};
GN ORFNames=OJ1119_A01.4-1 {ECO:0000312|EMBL:BAD22879.1},
GN P0474F11.19-1 {ECO:0000312|EMBL:BAD23111.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Lansheng;
RA Cao W.H., Dong Y., Zhang J.S., Chen S.Y.;
RT "Characterization of an ethylene receptor homolog gene from rice.";
RL Sci. China, Ser. C, Life Sci. 46:370-378(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=19417056; DOI=10.1105/tpc.108.065391;
RA Wuriyanghan H., Zhang B., Cao W.H., Ma B., Lei G., Liu Y.F., Wei W.,
RA Wu H.J., Chen L.J., Chen H.W., Cao Y.R., He S.J., Zhang W.K., Wang X.J.,
RA Chen S.Y., Zhang J.S.;
RT "The ethylene receptor ETR2 delays floral transition and affects starch
RT accumulation in rice.";
RL Plant Cell 21:1473-1494(2009).
CC -!- FUNCTION: Ethylene receptor related to bacterial two-component
CC regulators. Acts as negative regulator of ethylene signaling. May delay
CC the transition from the vegetative stage to the floral stage by up-
CC regulating GI (GIGANTEA) and RCN1 and cause starch accumulation in
CC stems by down-regulating the alpha-amylase AMY3D.
CC {ECO:0000269|PubMed:19417056}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000305};
CC -!- COFACTOR:
CC Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC Evidence={ECO:0000250|UniProtKB:P49333};
CC Note=Binds 1 copper ion per dimer. {ECO:0000250|UniProtKB:P49333};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:P49333}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q0DWC7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q0DWC7-2; Sequence=VSP_057847;
CC -!- DISRUPTION PHENOTYPE: Enhanced ethylene sensitivity and early
CC flowering. {ECO:0000269|PubMed:19417056}.
CC -!- SIMILARITY: Belongs to the ethylene receptor family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD22880.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAD23112.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF420318; AAL29303.2; -; mRNA.
DR EMBL; AP004020; BAD22879.1; -; Genomic_DNA.
DR EMBL; AP004020; BAD22880.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP004878; BAD23111.1; -; Genomic_DNA.
DR EMBL; AP004878; BAD23112.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP008208; BAF10461.1; -; Genomic_DNA.
DR EMBL; AP014958; BAS81626.1; -; Genomic_DNA.
DR EMBL; AP014958; BAS81627.1; -; Genomic_DNA.
DR EMBL; AK111520; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015626572.1; XM_015771086.1. [Q0DWC7-1]
DR RefSeq; XP_015626573.1; XM_015771087.1. [Q0DWC7-2]
DR AlphaFoldDB; Q0DWC7; -.
DR SMR; Q0DWC7; -.
DR STRING; 4530.OS02T0820900-03; -.
DR PaxDb; Q0DWC7; -.
DR PRIDE; Q0DWC7; -.
DR EnsemblPlants; Os02t0820900-01; Os02t0820900-01; Os02g0820900. [Q0DWC7-2]
DR EnsemblPlants; Os02t0820900-03; Os02t0820900-03; Os02g0820900. [Q0DWC7-1]
DR GeneID; 4331174; -.
DR Gramene; Os02t0820900-01; Os02t0820900-01; Os02g0820900. [Q0DWC7-2]
DR Gramene; Os02t0820900-03; Os02t0820900-03; Os02g0820900. [Q0DWC7-1]
DR KEGG; osa:4331174; -.
DR eggNOG; KOG0519; Eukaryota.
DR InParanoid; Q0DWC7; -.
DR OMA; MEMSADS; -.
DR OrthoDB; 253193at2759; -.
DR PlantReactome; R-OSA-5225756; Ethylene mediated signaling.
DR Proteomes; UP000000763; Chromosome 2.
DR Proteomes; UP000059680; Chromosome 2.
DR ExpressionAtlas; Q0DWC7; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0009873; P:ethylene-activated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:1902531; P:regulation of intracellular signal transduction; IEA:UniProt.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF47384; SSF47384; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR SUPFAM; SSF55874; SSF55874; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Coiled coil; Copper;
KW Endoplasmic reticulum; Ethylene signaling pathway; Kinase; Membrane;
KW Metal-binding; Nucleotide-binding; Receptor; Reference proteome;
KW Transferase; Transmembrane; Transmembrane helix;
KW Two-component regulatory system.
FT CHAIN 1..836
FT /note="Ethylene receptor 3"
FT /id="PRO_0000433867"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 269..413
FT /note="GAF"
FT /evidence="ECO:0000305"
FT DOMAIN 457..691
FT /note="Histidine kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT DOMAIN 718..834
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT COILED 416..452
FT /evidence="ECO:0000255"
FT BINDING 176
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000250|UniProtKB:P49333"
FT BINDING 180
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000250|UniProtKB:P49333"
FT VAR_SEQ 1..67
FT /note="MLLSTWTPGCFQGNKILLRSLITWYYLEFMPKLRPFYFLFYLTLPSCATDSP
FT PISDKSSSIFLPLAQ -> M (in isoform 2)"
FT /id="VSP_057847"
FT CONFLICT 99..102
FT /note="AARE -> PARQ (in Ref. 1; AAL29303)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 836 AA; 92620 MW; A4CA7B6F99DC2F33 CRC64;
MLLSTWTPGC FQGNKILLRS LITWYYLEFM PKLRPFYFLF YLTLPSCATD SPPISDKSSS
IFLPLAQQQQ LVHWMMPPRF RCQDYLLPLL LALSPAAAAA REVEYHHCHC DGGGGGGGGG
LWSMDSIFRW QKVSDLLIAA AYFSIPLEIL YFVAGLRHLL PFRWVLVQFG AFIVLCGLTH
LLTAFTYEPH PFMVVLLLTT AKFLTALVSF LTAITLLTLI PQLLRVKVRE SLLWLKAREL
DREVVLMKRQ EEASWHVRML THEIRKSLDR HTVLYTTLIE LSRVLGLTNC AVWMPAAGEM
CLTHELRRDG GGEDGVVGVD DADVVEVRGS DGVKLLGPDS VLAAASGGKE EGTGAVAAIR
MPMLKVSDFK GGTPEVIQTS YAVLVLVPPA GKSWGRHEME IVEVVAGQVA VALSHATLLE
ESRAMRDRLA EQNRELLQAR RDALMANEAR QAFQGVMSQG MRRPIHSILG LVSMVQEEAL
APEQRLVVDT MARTATVVST LVNDVMEMSA DSRERFPLET RPFHLHAMIR DAACVARCLC
DFRGFGFAVH VENALPDLVV GDERRIFHVL LHMVGNLIGR TEPGHVTLRV RAADDDVLDD
RLGQRWDPWW PSYSTGYSSV KFVIGVKRQQ NGDAGSPLSR RPSGKGIDLR LSFSMCRKLV
QMMQGNIWAI LDPQGLPESM TLVLRFQLQS PLTSSSLGGS FEQKHSSPSC QIAGLKVLLI
DDDDDINLVV ARKLLEKLGC VVSSPPSGSG FLSSVGSSAA AFQLVMVNLE MKRVKALDVA
TRISQYRSGR WPIVMAMASD QKAWEKCAQS GINGILKKPV ILQELKDELA RILQST
