ETR4_ORYSJ
ID ETR4_ORYSJ Reviewed; 777 AA.
AC Q7F239; A0A0P0X4E5; Q71HN7;
DT 16-SEP-2015, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Ethylene receptor 4 {ECO:0000305};
DE Short=OsETR4 {ECO:0000305};
DE EC=2.7.13.3 {ECO:0000305};
DE AltName: Full=OsPK3 {ECO:0000312|EMBL:AAQ07254.1};
GN Name=ETR4;
GN OrderedLocusNames=Os07g0259100 {ECO:0000312|EMBL:BAF21232.1},
GN LOC_Os07g15540 {ECO:0000305};
GN ORFNames=OJ1354_H07.118 {ECO:0000312|EMBL:BAC21334.1},
GN OJ1370_E02.107 {ECO:0000312|EMBL:BAD30215.1},
GN OsJ_23757 {ECO:0000312|EMBL:EAZ39331.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Lansheng;
RA Zhang J.-S., Dong Y., Cao W.-H., Chen S.-Y.;
RT "Rice ethylene receptor homolog OSPK3.";
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [7]
RP DISRUPTION PHENOTYPE.
RX PubMed=16891544; DOI=10.1104/pp.106.086371;
RA Pareek A., Singh A., Kumar M., Kushwaha H.R., Lynn A.M.,
RA Singla-Pareek S.L.;
RT "Whole-genome analysis of Oryza sativa reveals similar architecture of two-
RT component signaling machinery with Arabidopsis.";
RL Plant Physiol. 142:380-397(2006).
CC -!- FUNCTION: Ethylene receptor related to bacterial two-component
CC regulators. Acts as a redundant negative regulator of ethylene
CC signaling. {ECO:0000250|UniProtKB:P49333}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000305};
CC -!- COFACTOR:
CC Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC Evidence={ECO:0000250|UniProtKB:P49333};
CC Note=Binds 1 copper ion per dimer. {ECO:0000250|UniProtKB:P49333};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:P49333}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Late heading, altered kernel color and viviparous
CC phenotypes. {ECO:0000269|PubMed:16891544}.
CC -!- SIMILARITY: Belongs to the ethylene receptor family. {ECO:0000305}.
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DR EMBL; AF497626; AAQ07254.1; -; mRNA.
DR EMBL; AP003755; BAC21334.1; -; Genomic_DNA.
DR EMBL; AP003756; BAD30215.1; -; Genomic_DNA.
DR EMBL; AP008213; BAF21232.1; -; Genomic_DNA.
DR EMBL; AP014963; BAT00886.1; -; Genomic_DNA.
DR EMBL; CM000144; EAZ39331.1; -; Genomic_DNA.
DR EMBL; AK109593; BAG98813.1; -; mRNA.
DR RefSeq; XP_015646180.1; XM_015790694.1.
DR AlphaFoldDB; Q7F239; -.
DR STRING; 4530.OS07T0259100-01; -.
DR PaxDb; Q7F239; -.
DR PRIDE; Q7F239; -.
DR EnsemblPlants; Os07t0259100-01; Os07t0259100-01; Os07g0259100.
DR GeneID; 4342865; -.
DR Gramene; Os07t0259100-01; Os07t0259100-01; Os07g0259100.
DR KEGG; osa:4342865; -.
DR eggNOG; KOG0519; Eukaryota.
DR HOGENOM; CLU_000445_114_48_1; -.
DR InParanoid; Q7F239; -.
DR OMA; AAFTHAH; -.
DR OrthoDB; 431609at2759; -.
DR Proteomes; UP000000763; Chromosome 7.
DR Proteomes; UP000007752; Chromosome 7.
DR Proteomes; UP000059680; Chromosome 7.
DR Genevisible; Q7F239; OS.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0051740; F:ethylene binding; IBA:GO_Central.
DR GO; GO:0038199; F:ethylene receptor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR Gene3D; 3.30.450.40; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR014525; ETR.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR Pfam; PF01590; GAF; 1.
DR PIRSF; PIRSF026389; Ethyln_sen_HK; 1.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF47384; SSF47384; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Copper; Endoplasmic reticulum; Ethylene signaling pathway;
KW Kinase; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein;
KW Receptor; Reference proteome; Transferase; Transmembrane;
KW Transmembrane helix; Two-component regulatory system.
FT CHAIN 1..777
FT /note="Ethylene receptor 4"
FT /id="PRO_0000433869"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 184..344
FT /note="GAF"
FT /evidence="ECO:0000305"
FT DOMAIN 387..521
FT /note="Histidine kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT DOMAIN 645..774
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT BINDING 88
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000250|UniProtKB:P49333"
FT BINDING 92
FT /ligand="Cu cation"
FT /ligand_id="ChEBI:CHEBI:23378"
FT /evidence="ECO:0000250|UniProtKB:P49333"
FT MOD_RES 390
FT /note="Phosphohistidine; by autocatalysis"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT MOD_RES 696
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT CONFLICT 48
FT /note="D -> N (in Ref. 1; AAQ07254)"
FT /evidence="ECO:0000305"
FT CONFLICT 264
FT /note="G -> E (in Ref. 1; AAQ07254)"
FT /evidence="ECO:0000305"
FT CONFLICT 399
FT /note="V -> I (in Ref. 1; AAQ07254)"
FT /evidence="ECO:0000305"
FT CONFLICT 440
FT /note="T -> I (in Ref. 1; AAQ07254)"
FT /evidence="ECO:0000305"
FT CONFLICT 481
FT /note="P -> L (in Ref. 1; AAQ07254)"
FT /evidence="ECO:0000305"
FT CONFLICT 514
FT /note="G -> E (in Ref. 1; AAQ07254)"
FT /evidence="ECO:0000305"
FT CONFLICT 524
FT /note="V -> I (in Ref. 1; AAQ07254)"
FT /evidence="ECO:0000305"
FT CONFLICT 709
FT /note="R -> G (in Ref. 1; AAQ07254)"
FT /evidence="ECO:0000305"
FT CONFLICT 721
FT /note="N -> Y (in Ref. 1; AAQ07254)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 777 AA; 83177 MW; A84AF04EDCBBB15B CRC64;
MAMVTARQFL ASAAELGSGR RRCGGGGACD MREDGGVEAL MQCQRVSDLL IAASFLSIPL
ELFYFATCAD LSEVKCAVLH FCAFIVLCGA THLLAAFTHA HPHSAPLLRA LTAAKVLAAV
ASSAAAVSLL TFIPKLLRIK VRESLLRDKA SRLHRDLGLV RRREEATSRA VRELTGRIRA
SPPDAHAILR TTALQLADAL GLHACAVWMP AAGRPHDLVL VHHLTSRPDD AADLLLEVGD
ACTVAADDPD VVDVMASKVA KVLGPDSALA MASSVGAAPA GAVAAIRIPI LRVSIYDGGG
TPEVTEASYA ILVLLLPPHD AAGGWSSHDL EIVQVVADQA AVALSHAAVL EESRSMRDRF
AEQHRALMQA KHRAAMATRA FSSIQSAMCH AMRRPVHSVV GLVSMLQHPE ADTMRPEQRL
AVDAIARTSN LLSALMDEVT VNRQHLSVQR KPFSLHALIK EAISVAGCLS HCGGAGFLHQ
PECALPEWVV GDERRVFHLL LDMVGTLLNR CNTGSGACRL SFSVRICNVG EERYSLDWIP
MRPTFSGCNV CVKFKVGIGR SRSCAIERSL PCELPRRSAA TTSSQMGHIF SGYFNKIVQM
MNGNMWSASD SEGVGESVTL ILQFKLQQGH VEASPPYIPH LNGLRVLLAD DDAMNRGVTK
KILERLGCQV MSAPSGAHCL SLLASAEASF QLVVLDLDDR AVPSAAMDRF EVALRIRELR
NSCWLLIVIA VAAGVVATDD GGAVQELCQR AGINGLVQKP VTLPALGAQL CRVLQDN
