ID   ETRA_SHEON              Reviewed;         250 AA.
AC   P46148;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2002, sequence version 2.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Electron transport regulator A;
GN   Name=etrA; OrderedLocusNames=SO_2356;
OS   Shewanella oneidensis (strain MR-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=211586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MR-1;
RX   PubMed=8253682; DOI=10.1128/jb.175.24.7938-7944.1993;
RA   Saffarini D.A., Nealson K.H.;
RT   "Sequence and genetic characterization of etrA, an fnr analog that
RT   regulates anaerobic respiration in Shewanella putrefaciens MR-1.";
RL   J. Bacteriol. 175:7938-7944(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MR-1;
RX   PubMed=12368813; DOI=10.1038/nbt749;
RA   Heidelberg J.F., Paulsen I.T., Nelson K.E., Gaidos E.J., Nelson W.C.,
RA   Read T.D., Eisen J.A., Seshadri R., Ward N.L., Methe B.A., Clayton R.A.,
RA   Meyer T., Tsapin A., Scott J., Beanan M.J., Brinkac L.M., Daugherty S.C.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Haft D.H., Kolonay J.F., Madupu R.,
RA   Peterson J.D., Umayam L.A., White O., Wolf A.M., Vamathevan J.J.,
RA   Weidman J.F., Impraim M., Lee K., Berry K.J., Lee C., Mueller J.,
RA   Khouri H.M., Gill J., Utterback T.R., McDonald L.A., Feldblyum T.V.,
RA   Smith H.O., Venter J.C., Nealson K.H., Fraser C.M.;
RT   "Genome sequence of the dissimilatory metal ion-reducing bacterium
RT   Shewanella oneidensis.";
RL   Nat. Biotechnol. 20:1118-1123(2002).
CC   -!- FUNCTION: Regulates anaerobic growth on fumarate, nitrite, Fe(3+),
CC       TMAO, DMSO, thiosulfate and sulfite, but not on nitrate nor Mn(4+).
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Possesses 4 cysteines which may bind a metal ion
CC       (possibly iron).
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DR   EMBL; L13868; AAA71987.1; -; Unassigned_DNA.
DR   EMBL; AE014299; AAN55390.2; -; Genomic_DNA.
DR   PIR; A49910; A49910.
DR   RefSeq; NP_717946.2; NC_004347.2.
DR   RefSeq; WP_011072343.1; NZ_CP053946.1.
DR   AlphaFoldDB; P46148; -.
DR   SMR; P46148; -.
DR   STRING; 211586.SO_2356; -.
DR   PaxDb; P46148; -.
DR   KEGG; son:SO_2356; -.
DR   PATRIC; fig|211586.12.peg.2267; -.
DR   eggNOG; COG0664; Bacteria.
DR   HOGENOM; CLU_075053_0_2_6; -.
DR   OMA; SICRIHK; -.
DR   OrthoDB; 1587662at2; -.
DR   PhylomeDB; P46148; -.
DR   BioCyc; SONE211586:G1GMP-2154-MON; -.
DR   Proteomes; UP000008186; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IMP:TIGR.
DR   GO; GO:0009061; P:anaerobic respiration; IMP:TIGR.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:TIGR.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR012318; HTH_CRP.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR018335; Tscrpt_reg_HTH_Crp-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00325; Crp; 1.
DR   PRINTS; PR00034; HTHCRP.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00419; HTH_CRP; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS00042; HTH_CRP_1; 1.
DR   PROSITE; PS51063; HTH_CRP_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..250
FT                   /note="Electron transport regulator A"
FT                   /id="PRO_0000100155"
FT   DOMAIN          164..237
FT                   /note="HTH crp-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT   DNA_BIND        197..216
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT   CONFLICT        30
FT                   /note="I -> M (in Ref. 1; AAA71987)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        64
FT                   /note="P -> L (in Ref. 1; AAA71987)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        72
FT                   /note="R -> P (in Ref. 1; AAA71987)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   250 AA;  27889 MW;  24C82E3C8C3E5743 CRC64;
     MTIEQNKNRR SAASGCAIHC HDCSMGTLCI PFTLNANELD QLDDIIERKK PIQKGEQIFK
     SGDPLKSLFA IRSGTIKSYT ITEQGDEQIT GFHLAGDVIG FDGIHAQSHQ SFAQALETSM
     VCEIPFNILD ELSGTMPKLR QQIMRLMSNE IMSDQEMILL LSKKNAEERL AAFISNLANR
     FGNRGFSAKE FRLTMTRGDI GNYLGLTVET ISRLLGRFQK SGLIEVKGKY IIIVDHHELN
     LLAGNARIAR