ETS1A_CHICK
ID ETS1A_CHICK Reviewed; 441 AA.
AC P13474;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Transforming protein p54/c-ets-1;
GN Name=ETS1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Spleen;
RX PubMed=3041344;
RA Duterque-Coquillaud M., Leprince D., Flourens A., Henry C., Ghysdael J.,
RA Debuire B., Stehelin D.;
RT "Cloning and expression of chicken p54c-ets cDNAs: the first p54c-ets
RT coding exon is located into the 40.0 kbp genomic domain unrelated to v-
RT ets.";
RL Oncogene Res. 2:335-344(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Spleen;
RX PubMed=3041346;
RA Chen J.H.;
RT "Complementary DNA clones of chicken proto-oncogene c-ets: sequence
RT divergence from the viral oncogene v-ets.";
RL Oncogene Res. 2:371-384(1988).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2847407; DOI=10.1016/0042-6822(88)90047-5;
RA Watson D.K., McWilliams M.J., Papas T.S.;
RT "A unique amino-terminal sequence predicted for the chicken proto-ets
RT protein.";
RL Virology 167:1-7(1988).
RN [4]
RP ALTERNATIVE PROMOTER USAGE.
RX PubMed=8268721;
RA Crepieux P., Leprince D., Flourens A., Albagli O., Ferreira E.,
RA Stehelin D.;
RT "The two functionally distinct amino termini of chicken c-ets-1 products
RT arise from alternative promoter usage.";
RL Gene Expr. 3:215-225(1993).
CC -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC -!- SUBUNIT: Binds DNA as a homodimer; homodimerization is required for
CC transcription activation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P14921}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative promoter usage; Named isoforms=2;
CC Name=p54;
CC IsoId=P13474-1; Sequence=Displayed;
CC Name=p68;
CC IsoId=P15062-1; Sequence=External;
CC -!- TISSUE SPECIFICITY: Thymus.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR EMBL; M22462; AAA48764.1; -; mRNA.
DR EMBL; X13026; CAA31441.1; -; mRNA.
DR EMBL; X13027; CAA31442.1; -; mRNA.
DR PIR; A31285; TVCHTE.
DR RefSeq; NP_990629.2; NM_205298.2. [P13474-1]
DR AlphaFoldDB; P13474; -.
DR SMR; P13474; -.
DR iPTMnet; P13474; -.
DR GeneID; 396235; -.
DR KEGG; gga:396235; -.
DR CTD; 2113; -.
DR VEuPathDB; HostDB:geneid_396235; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
DR GO; GO:0045765; P:regulation of angiogenesis; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd08542; SAM_PNT-ETS-1; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.150.50; -; 1.
DR InterPro; IPR045688; Ets1_N_flank.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041886; SAM_PNT-ETS-1.
DR InterPro; IPR016311; Transform_prot_C-ets.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; PTHR11849; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF19525; Ets1_N_flank; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PIRSF; PIRSF001698; Transforming_factor_C-ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 2: Evidence at transcript level;
KW Alternative promoter usage; DNA-binding; Nucleus; Phosphoprotein;
KW Proto-oncogene; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..441
FT /note="Transforming protein p54/c-ets-1"
FT /id="PRO_0000204072"
FT DOMAIN 51..136
FT /note="PNT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT DNA_BIND 335..415
FT /note="ETS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT REGION 130..243
FT /note="Activation domain; required for transcription
FT activation"
FT /evidence="ECO:0000250"
FT MOD_RES 38
FT /note="Phosphothreonine; by MAPK"
FT /evidence="ECO:0000250"
FT CONFLICT 117
FT /note="R -> A (in Ref. 3; AAA48764)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 441 AA; 50327 MW; 5CF3C575CCE115F5 CRC64;
MKAAVDLKPT LTIIKTEKVD IDLFPSPDME CADVPLLTPS SKEMMSQALK ATFSGFAKEQ
QRLGIPKDPQ QWTETHVRDW VMWAVNEFSL KGVDFQKFCM NGAALCALGK ECFLELRPDF
VGDILWEHLE ILQKEEAKPY PANGVNAAYP ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF
ITESYQTLHP ISSEELLSLK YENDYPSVIL RDPVQTDSLQ TDYFTIKQEV VTPDNMCMGR
ASRGKLGGQD SFESIESYDS CDRLTQSWSS QSSFQSLQRV PSYDSFDSED YPAALPNHKP
KGTFKDYVRD RADMNKDKPV IPAAALAGYT GSGPIQLWQF LLELLTDKSC QSFISWTGDG
WEFKLSDPDE VARRWGKRKN KPKMNYEKLS RGLRYYYDKN IIHKTAGKRY VYRFVCDLQS
LLGYTPEELH AMLDVKPDAD E
