ETS1B_CHICK
ID ETS1B_CHICK Reviewed; 485 AA.
AC P15062;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Transforming protein p68/c-ets-1;
GN Name=ETS1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2841475; DOI=10.1128/jvi.62.9.3233-3241.1988;
RA Leprince D., Duterque-Coquillaud M., Li R.-P., Henry C., Flourens A.,
RA Debuire B., Stehelin D.;
RT "Alternative splicing within the chicken c-ets-1 locus: implications for
RT transduction within the E26 retrovirus of the c-ets proto-oncogene.";
RL J. Virol. 62:3233-3241(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3284179; DOI=10.1016/0042-6822(88)90624-1;
RA Watson D.K., McWilliams M.J., Papas T.S.;
RT "Molecular organization of the chicken ets locus.";
RL Virology 164:99-105(1988).
RN [3]
RP ALTERNATIVE PROMOTER USAGE.
RX PubMed=8268721;
RA Crepieux P., Leprince D., Flourens A., Albagli O., Ferreira E.,
RA Stehelin D.;
RT "The two functionally distinct amino termini of chicken c-ets-1 products
RT arise from alternative promoter usage.";
RL Gene Expr. 3:215-225(1993).
CC -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC -!- SUBUNIT: Binds DNA as a homodimer; homodimerization is required for
CC transcription activation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P14921}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative promoter usage; Named isoforms=2;
CC Name=p68;
CC IsoId=P15062-1; Sequence=Displayed;
CC Name=p54;
CC IsoId=P13474-1; Sequence=External;
CC -!- TISSUE SPECIFICITY: Spleen.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA48668.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M21823; AAA48669.1; -; mRNA.
DR EMBL; AH002441; AAA48668.1; ALT_INIT; Genomic_DNA.
DR PIR; A28875; TVCHET.
DR RefSeq; XP_015153455.1; XM_015297969.1. [P15062-1]
DR AlphaFoldDB; P15062; -.
DR SMR; P15062; -.
DR STRING; 9031.ENSGALP00000001717; -.
DR PaxDb; P15062; -.
DR GeneID; 396235; -.
DR CTD; 2113; -.
DR VEuPathDB; HostDB:geneid_396235; -.
DR eggNOG; KOG3806; Eukaryota.
DR InParanoid; P15062; -.
DR PhylomeDB; P15062; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
DR GO; GO:0045765; P:regulation of angiogenesis; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd08542; SAM_PNT-ETS-1; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.150.50; -; 1.
DR InterPro; IPR045688; Ets1_N_flank.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041886; SAM_PNT-ETS-1.
DR InterPro; IPR016311; Transform_prot_C-ets.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; PTHR11849; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF19525; Ets1_N_flank; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PIRSF; PIRSF001698; Transforming_factor_C-ets; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF47769; SSF47769; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 2: Evidence at transcript level;
KW Alternative promoter usage; DNA-binding; Nucleus; Proto-oncogene;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..485
FT /note="Transforming protein p68/c-ets-1"
FT /id="PRO_0000204073"
FT DOMAIN 95..180
FT /note="PNT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT DNA_BIND 379..459
FT /note="ETS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT REGION 174..287
FT /note="Activation domain; required for transcription
FT activation"
FT /evidence="ECO:0000250"
FT CONFLICT 220
FT /note="S -> C (in Ref. 2; AAA48668)"
FT /evidence="ECO:0000305"
FT CONFLICT 222
FT /note="P -> R (in Ref. 2; AAA48668)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 485 AA; 55021 MW; 81576B43BEF62648 CRC64;
MMSYYMDTTI GSTGPYPLAR PGVMQGASSC CEDPWMPCRL QSACCPPRSC CPPWDEAAIQ
EVPTGLEHYS TDMECADVPL LTPSSKEMMS QALKATFSGF AKEQQRLGIP KDPQQWTETH
VRDWVMWAVN EFSLKGVDFQ KFCMNGAALC ALGKECFLEL APDFVGDILW EHLEILQKEE
AKPYPANGVN AAYPESRYTS DYFISYGIEH AQCVPPSEFS EPSFITESYQ TLHPISSEEL
LSLKYENDYP SVILRDPVQT DSLQTDYFTI KQEVVTPDNM CMGRASRGKL GGQDSFESIE
SYDSCDRLTQ SWSSQSSFQS LQRVPSYDSF DSEDYPAALP NHKPKGTFKD YVRDRADMNK
DKPVIPAAAL AGYTGSGPIQ LWQFLLELLT DKSCQSFISW TGDGWEFKLS DPDEVARRWG
KRKNKPKMNY EKLSRGLRYY YDKNIIHKTA GKRYVYRFVC DLQSLLGYTP EELHAMLDVK
PDADE
