ID   ETS1B_XENLA             Reviewed;         268 AA.
AC   P18756;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Protein c-ets-1-B;
DE            Short=C-ets-1B;
DE   AltName: Full=XE1-B;
DE   Flags: Fragment;
GN   Name=ets1-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RX   PubMed=2205841; DOI=10.1093/nar/18.17.5298;
RA   Stiegler P., Wolff C.M., Baltzinger M., Hirzlin J., Senan F., Meyer D.,
RA   Ghysdael J., Stehelin D., Befort N., Remy P.;
RT   "Characterization of Xenopus laevis cDNA clones of the c-ets-1 proto-
RT   oncogene.";
RL   Nucleic Acids Res. 18:5298-5298(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RA   Salvati A.L., Morabito S., Merendino X., Carnevali F.;
RL   Submitted (APR-1992) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable transcription factor. {ECO:0000250}.
CC   -!- SUBUNIT: Binds DNA as a homodimer; homodimerization is required for
CC       transcription activation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P14921}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR   EMBL; X52691; CAA36918.1; -; mRNA.
DR   EMBL; X65166; CAA46284.1; -; mRNA.
DR   PIR; S11224; S11224.
DR   AlphaFoldDB; P18756; -.
DR   SMR; P18756; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.
DR   GO; GO:0045765; P:regulation of angiogenesis; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR045688; Ets1_N_flank.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; PTHR11849; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF19525; Ets1_N_flank; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           <1..268
FT                   /note="Protein c-ets-1-B"
FT                   /id="PRO_0000204075"
FT   DNA_BIND        162..242
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT   MOD_RES         109
FT                   /note="Phosphoserine; by CaMK"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   268 AA;  30772 MW;  EB0D745C642C0107 CRC64;
     EFSEPSFITE SYQTLHPISS EELLSLKYES DYPLGLLRDP LQPESLQGDY FTIKQEVVSP
     DNMCLGRISR GKLGGQESFE SIESHDSCDR LTQSWSSQSS YNSLQRVPSY DSFDSEDYPP
     ALPSHKSKGT FKDYVRDRAE LNKDKPVIPA AALAGYTGSG PIQLWQFLLE LLTDKSCQSF
     ISWTGDGWEF KLSDPDEVAR RWGKRKNKPK MNYEKLSRGL RYYYDKNIIH KTAGKRYVYR
     FVCDLQSLLG YVPEELHAML DVKPDTDE